Results 51 to 60 of about 3,779,091 (351)

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Recommendation of Active Employment Policy Based on Entrepreneurship and Social Innovation: Social Entrepreneurship Support Model for Youth in Turkey

Istanbul Business Research, 2022
In this study, the social entrepreneurship support model will be designed in Turkey as an active employment policy proposal based on entrepreneurship and social innovation in the fight against youth unemployment.
Volkan Işık
doaj   +1 more source

SERS Facemask for Rapid and Portable Sensing Mycobacterium Tuberculosis Antigens for TB Screening

Advanced Science, EarlyView.
Our study introduced an Au─Ag embedded covalent organic framework (U@COF) ‐mediated facemask for sensing TB antigen ESAT‐6/CFP‐10 complex in clinical droplet samples toward TB screening. Practical analysis of clinical samples demonstrated the availability of our facemask, which is capable of identifying the TB subjects (N = 17) from healthy candidates (
Lingzhi Chen, Jiaqi Yu, Jing Xu, Lingqi Chen, Ninghao Zhang, Wenrui Li, Runmin Zeng, Xiaomin Luo, Yiqun Chang, Jiayin Lai, Wenshi Huang, Xiaochen Liang, Ting Zhao, Shanze Chen, Huaihong Cai, Yanguang Cong, Pinghua Sun, Jiang Pi, Xueqin Huang, Haibo Zhou, Junxia Zheng   +20 more
wiley   +1 more source

Toward sustainable rural revitalization: the role of entrepreneurship training in the development of farmers' entrepreneurial dynamic capabilities

Frontiers in Sustainable Food Systems
IntroductionEncouraging farmers to engage in entrepreneurship is a core pathway to advance rural revitalization, and their entrepreneurial dynamic capabilities serve as a critical foundation for the sustainable success of entrepreneurial ventures and ...
Lanlan Liu, Lanlan Liu, Xi Ding, Jia Wu
doaj   +1 more source

Practical aspects of writing а high-quality final qualifying work in the profile “entrepreneurship”

Современная конкуренция, 2020
This article discusses the practical aspects of writing a high-quality final qualifying work in the profile “Entrepreneurship” of the higher education curriculum.
M. P. Sadovnikova
doaj   +1 more source

Moderated Mediating Mechanism Effects of Chinese University Entrepreneurship Education on Independent Student Entrepreneurship

Frontiers in Psychology, 2022
Entrepreneurship education plays a mediating moderating role in independent entrepreneurship, especially for the fresh graduates where entrepreneurial knowledge charms.
Yuhui Li, Yimin Sha, Yijun Lv, Yenchun Jim Wu, Yenchun Jim Wu, Haiming Liu   +5 more
doaj   +1 more source

Discovery and Engineering of a Rat Endogenous Retrovirus Reverse Transcriptase for Efficient Prime Editing

Advanced Science, EarlyView.
We screened 558 reverse transcriptases and engineered an optimized rat endogenous retrovirus‐derived variant, enRERV‐RT, via structure‐guided engineering and deep mutational scanning. This enhanced prime editor, based on the engineered RT, outperforms conventional M‐MLV‐RT systems across plant and animal cells, particularly at hard‐to‐edit loci ...
Linsha Ma, Pengcheng Yao, Shengqi Wu, Yuanyuan Shi, Lang Qin, Baitao Li, Jiayi Zhu, Minhua Huang, Yichong Zhu, Yuwen Song, Jinhuan Pang, Ziping Guo, Guochuan Wu, Chen Wang, Kewei Xu, Ruihua Huang, Quan Kuang, Liang Qu, Changtian Pan, Xianrong Xie, Qinlong Zhu, Jiaying Huang, Qiupeng Lin   +22 more
wiley   +1 more source

RUSSIA'S ECONOMIC SECURITY: THREATS TO NATIONAL INTERESTS AND THEIR REFLECTION

Модернизация, инновация, развитие, 2015
The relevance of this study due to the fact that at the present time the situation inRussiais complemented by the negative consequences of market reforms in the economy.
M. N. Dudin, N. V. Ljasnikov, V. N. Sidorenko   +2 more
doaj  

Entrepreneurship Education in India: Barriers and Strategic Reforms for an Inclusive Innovation Ecosystem

Journal of Asia Entrepreneurship and Sustainability
Entrepreneurship education is increasingly recognised as a critical driver of inclusive innovation, employability, and economic growth, particularly in emerging economies like India.
Venkataram Bhat
doaj   +1 more source