Results 181 to 190 of about 449,947 (310)

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Navigating polymorph generation and distilled-potential development via entropy-symmetry landscapes for metal plasticity mechanisms. [PDF]

Nat Commun
Li Z, Liu T, Wan X, Zhao S, Zhang Z, Zhou E, Yu W, Zuo Y, Robertson J, Liu S, Guo Y.   +10 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Finite-Capacity Thermodynamics of Causal Horizons. [PDF]

Entropy (Basel)
Antiba CA.
europepmc   +1 more source

A minimum cross entropy model to generate disaggregated agricultural data at the local level

This work presents an entropy approach to disaggregate agricultural data at a local level. It comprises two different steps. In a first one, an information prior at disaggregated level based on experts’ opinions, available cartography of land use and ...
Fragoso, Rui Manuel de Sousa, Martins, Maria de Belem, Xavier, Antonio   +2 more
core  

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Entropy-Guided Sedation Is Associated with Improved Hemodynamic Stability and Recovery During ERCP: A Prospective Real-World Cohort Study. [PDF]

J Clin Med
Popovici SE, Ritiu SA, Miutescu B, Moga TV, Sporea I, Sandesc D, Bedreag O, Păpurică M, Lupusoru R, Popescu A.   +9 more
europepmc   +1 more source

ESTIMATING NON-PARAMETRIC AND PARAMETRIC TRANSFORMATION FUNCTIONS FROM SURVEY DATA: AN APPLICATION OF MINIMUM CROSS-ENTROPY

A model of a (convex) technology of representative and non-representative firms in a heterogeneous sector is presented in non-parametric and parametric versions. The heterogeneity is specified with error terms.
Hoveid, Oyvind
core  

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

A Stylometric Analog of the Fermi-Pasta-Ulam-Tsingou Problem: Combination of Human Bias and Long-Range Correlation Creates a Sort of Soliton. [PDF]

Entropy (Basel)
Hayata K.
europepmc   +1 more source