Results 211 to 220 of about 1,285,086 (339)

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

An entropy-based study of Simplification in ChatGPT translations compared to neural machine translation and human translation across genres. [PDF]

PLoS One
Yao G, Fan L.
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Extreme Values and Convergence of the Voronoi Entropy for 2D Random Point Processes and for Long-Range Order. [PDF]

Entropy (Basel)
Frenkel M, Legchenkova I, Bormashenko E, Shoval S, Nosonovsky M.   +4 more
europepmc   +1 more source

Validator-Certified Resolution of Gravitational Reversal via Spectral-Motivic Geometry, Entropy Threshold Activation, and Homological Sealing: A Modular Framework for Analytic, Computational, and Instructional Replication

Forrest M. Anderson, Forrest
openalex   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Quantifying the compressibility of the human brain. [PDF]

Proc Natl Acad Sci U S A
Weaver NJ, Faskowitz J, Betzel RF, Lynn CW.   +3 more
europepmc   +1 more source

Dissimilar fusion welding of NiTi shape memory alloy and AlCoCrFeNi2.1 eutectic high entropy alloy using multi-interlayer strategy

Nithin Joseph Reddy Sagili Arthur, Rae Eon Kim, Ana Martins, Hyoung Seop Kim, Norbert Schell, Joao P. Oliveira   +5 more
openalex   +1 more source

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

Unifying thermopower: entropy and specific heat in magnetic, superconducting, nanoscale, and frustrated systems. [PDF]

iScience
Jazandari M, Abouie J, Vashaee D.
europepmc   +1 more source