Results 21 to 30 of about 26,306 (212)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

A topological signature of multipartite entanglement [PDF]

, 2019
In this manuscript, we present a proposal to relate topological structure of worldline configurations to multipartite entanglement. Configurations result from the path-integral formulation of the density matrix in the limit of zero temperature.
Capogrosso-Sansone, Barbara, Lingua, Fabio, Shpani, Liana, Wang, Wei   +3 more
core   +3 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Noncommutative Spectral Invariants and Black Hole Entropy

, 2004
We consider an intrinsic entropy associated with a local conformal net A by the coefficients in the expansion of the logarithm of the trace of the ``heat kernel'' semigroup.
Araki, Ashtekar, Bekenstein, Bekenstein, Buchholz, Böckenhauer, Cardy, Carlip, Chamseddine, Connes, Doplicher, Fröhlich, Guido, Guido, Guido, Haagerup, Jones, Kac, Kac, Kawahigashi, Kawahigashi, Kosaki, Longo, Longo, Longo, Longo, Longo, Longo, Maldacena, Moretti, Pimsner, Rehren, Rehren, Roberto Longo, Schroer, Schroer, Strominger, Summers, Susskind, Takesaki, Xu, Yasuyuki Kawahigashi   +41 more
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Modified Gravity with Nonminimal Curvature–Matter Couplings: A Framework for Gravitationally Induced Particle Creation

Universe
Modified gravity theories with a nonminimal coupling between curvature and matter offer a compelling alternative to dark energy and dark matter by introducing an explicit interaction between matter and curvature invariants.
Francisco S. N. Lobo, Tiberiu Harko, Miguel A. S. Pinto   +2 more
doaj   +1 more source

A Curvature Principle for the interaction between universes

, 2007
We propose a Curvature Principle to describe the dynamics of interacting universes in a multi-universe scenario and show, in the context of a simplified model, how interaction drives the cosmological constant of one of the universes toward a vanishingly ...
A. Linde, D.A. Easson, D.A. Easson, E.J. Copeland, G. ’t Hooft, J. Mcdonald, K. Olive, L Susskind, M Markov, M. Markov, M.C. Bento, M.C. Bento, M.C. Bento, M.C. Bento, M.C. Bento, M.C. Bento, M.C. Bento, O. Bertolami, O. Bertolami, O. Bertolami, O. Bertolami, O. Bertolami, O. Bertolami, O. Bertolami, O. Bertolami, Orfeu Bertolami, P.T. Silva, R. Bousso, R. Bousso, R.H. Brandenberger, S Coleman, S. Carroll, S. Weinberg, W. Fischler, W. Unruh, W. Unruh   +35 more
core   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Measures of gravitational entropy I. Self-similar spacetimes

, 2000
We examine the possibility that the gravitational contribution to the entropy of a system can be identified with some measure of the Weyl curvature. In this paper we consider homothetically self-similar spacetimes. These are believed to play an important
B. J. Carr, B. O’Neill, K. Anguige, K. Yano, Kayll Lake, Nicos Pelavas, R. Penrose, S. M. Scott, S. W. Goode, T. Rothman, W. B. Bonnor   +10 more
core   +1 more source

U-Invariants, Black-Hole Entropy and Fixed Scalars [PDF]

, 1997
The absolute (moduli-independent) U-invariants of all N>2 extended supergravities at D=4 are derived in terms of (moduli-dependent) central and matter charges.
Andrianopoli, Andrianopoli, Andrianopoli, Behrndt, Bergshoeff, Breitenlohner, Callan, Castellani, Cecotti, Ceresole, Cremmer, Cvetic, Cvetic, Cvetic, Cvetic, de Roo, Dijkgraaf, Dixon, Duff, Duff, Duff, Ferrara, Ferrara, Ferrara, Ferrara, Ferrara, Ferrara, Ferrara, Ferrara, Ferrara, Gibbons, Gibbons, Gibbons, Gibbons, Gilmore, Horowitz, Horowitz, Hull, Julia, Kallosh, Kallosh, Kallosh, Kallosh, Kallosh, Kaplan, Larsen, Laura Andrianopoli, Maldacena, Riccardo D'Auria, Schwarz, Seiberg, Sen, Sen, Sen, Sergio Ferrara, Strominger, Strominger, Susskind, Susskind   +58 more
core   +2 more sources