Results 31 to 40 of about 26,306 (212)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Elliptic Curves and Hyperdeterminants in Quantum Gravity [PDF]

, 2010
Hyperdeterminants are generalizations of determinants from matrices to multi-dimensional hypermatrices. They were discovered in the 19th century by Arthur Cayley but were largely ignored over a period of 100 years before once again being recognised as ...
Gibbs, Philip
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Multidimensional simple waves in fully relativistic fluids

, 2008
A special version of multi--dimensional simple waves given in [G. Boillat, {\it J. Math. Phys.} {\bf 11}, 1482-3 (1970)] and [G.M. Webb, R. Ratkiewicz, M. Brio and G.P. Zank, {\it J.
Akhiezer A I, Ali Mahdipour-Shirayeh, Anile A M, Burnat M, Burnat M, Burnat M, Burnat M, Cabannes H, Caffarelli L, Chorin A J, Courant R, Dafermos C M, Homayoon Eshraghi, Ibragimov N H, John F, Komarovskii L V, Landau L D, Lichnerowicz A, Lichnerowicz A, P K Shukla, Peradzynski Z, Peradzynski Z, Rozdestvenskii B L, Shikin I S, Smoller J, Taliya Sahihi, Von Mises R, Webb G M, Zajaczkowski W   +28 more
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

New higher-derivative invariants in N=2 supergravity and the Gauss-Bonnet term [PDF]

, 2013
A new class of N=2 locally supersymmetric higher-derivative invariants is constructed based on logarithms of conformal primary chiral superfields. They characteristically involve a coupling to R_{\mu\nu}^2 - 1/3*R^2, which equals the non-conformal part ...
Butter, Daniel, de Wit, Bernard, Kuzenko, Sergei M., Lodato, Ivano   +3 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Extremal Black Holes in Supergravity and the Bekenstein-Hawking Entropy

, 2002
We review some results on the connection among supergravity central charges, BPS states and Bekenstein-Hawking entropy. In particular, N=2 supergravity in four dimensions is studied in detail.
Andrianopoli, L., D'Auria, R.
core   +2 more sources

Observations on Integral and Continuous U-duality Orbits in N=8 Supergravity [PDF]

, 2010
One would often like to know when two a priori distinct extremal black p-brane solutions are in fact U-duality related. In the classical supergravity limit the answer for a large class of theories has been known for some time.
A Marrani, Banerjee S, Banerjee S, Banerjee S, Bianchi M Ferrara S Kallosh R, Borsten L Dahanayake D Duff M J Rubens W, Cerchiai B L Ferrara S Marrani A Zumino B, Ceresole A, D Dahanayake, Dabholkar A, Duff M J, Faulkner J R, Ferrar C J, Ferrara S, Freudenthal H, Gaiotto D, Gunaydin M Pavlyk O, Jacobson N, Jacobson N, Jordan P, Kantor I, L Borsten, Lu H, M J Duff, Maldacena J M Moore G W Strominger A, McCrimmon K, McCrimmon K, Pioline B, S Ferrara, Sen A, Sen A, Springer T A, Sudbery A, W Rubens   +33 more
core   +3 more sources