Results 101 to 110 of about 72,650 (303)
The role of quantum measurement in stochastic thermodynamics
npj Quantum Information, 2017 Rebuilding quantum thermodynamics on quantum measurement Measuring a quantum system is an ultimately random operation. It induces a genuinely quantum time arrow, increasing the system’s entropy. But because it perturbs its state, quantum measurement also
Cyril Elouard +3 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
The Maximum Entropy Principle in the Absence of a Time-Arrow: Fractional-Pole Models [PDF]
IEEE Transactions on Information Theory, 2007 The maximum entropy (ME) principle, as it is often invoked in the context of time-series analysis, suggests the selection of a power spectrum which is consistent with autocorrelation data and corresponds to a random process least predictable from past observations. We introduce and compare a class of spectra with the property that the underlying random
openaire +1 more source
On the nature of cosmological time [PDF]
, 2015 Time is a parameter playing a central role in our most fundamental modeling of natural laws. Relativity theory shows that the comparison of times measured by different clocks depends on their relative motions and on the strength of the gravitational ...
Hauret, Clémentine, Magain, Pierre
core
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Memory Systems, the Epistemic Arrow of Time, and the Second Law
EntropyThe epistemic arrow of time is the fact that our knowledge of the past seems to be both of a different kind and more detailed than our knowledge of the future. Just like with the other arrows of time, it has often been speculated that the epistemic arrow
David H. Wolpert, Jens Kipper
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Entropic constraint on cosmic variation of Planck mass and the Boltzmann constant
Results in PhysicsIn cosmology, cosmic variations of fundamental constraints are constrained by the arrow of time of astrophysical black holes, given the Bekenstein–Hawking entropy S∼kBM/mp2 of their event horizon parameterized by black hole mass M and the Planck mass mp ...
Maurice H.P.M. van Putten
doaj +1 more source