Results 101 to 110 of about 69,539 (295)

Small and Simple Systems That Favor the Arrow of Time

open access: yesEntropy
The 2nd law of thermodynamics yields an irreversible increase in entropy until thermal equilibrium is achieved. This irreversible increase is often assumed to require large and complex systems to emerge from the reversible microscopic laws of physics. We
Ralph V. Chamberlin
doaj   +1 more source

The role of quantum measurement in stochastic thermodynamics

open access: yesnpj Quantum Information, 2017
Rebuilding quantum thermodynamics on quantum measurement Measuring a quantum system is an ultimately random operation. It induces a genuinely quantum time arrow, increasing the system’s entropy. But because it perturbs its state, quantum measurement also
Cyril Elouard   +3 more
doaj   +1 more source

On the nature of cosmological time [PDF]

open access: yes, 2015
Time is a parameter playing a central role in our most fundamental modeling of natural laws. Relativity theory shows that the comparison of times measured by different clocks depends on their relative motions and on the strength of the gravitational ...
Hauret, Clémentine, Magain, Pierre
core  

TRPM8 levels determine tumor vulnerability to channel agonists

open access: yesMolecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo   +18 more
wiley   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

open access: yesMolecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton   +17 more
wiley   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

open access: yesMolecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop   +10 more
wiley   +1 more source

Memory Systems, the Epistemic Arrow of Time, and the Second Law

open access: yesEntropy
The epistemic arrow of time is the fact that our knowledge of the past seems to be both of a different kind and more detailed than our knowledge of the future. Just like with the other arrows of time, it has often been speculated that the epistemic arrow
David H. Wolpert, Jens Kipper
doaj   +1 more source

Thermodynamics: The Unique Universal Science

open access: yesEntropy, 2017
Thermodynamics is a physical branch of science that governs the thermal behavior of dynamical systems from those as simple as refrigerators to those as complex as our expanding universe.
Wassim M. Haddad
doaj   +1 more source

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

open access: yesMolecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed   +8 more
wiley   +1 more source

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