Results 71 to 80 of about 72,650 (303)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Does time exist in quantum gravity?
Zagadnienia Filozoficzne w Nauce, 2015 Time is absolute in standard quantum theory and dynamical in general relativity. The combination of both theories into a theory of quantum gravity leads therefore to a “problem of time”.
Claus Kiefer
doaj
Zygon, 1984 . This paper explores a possible relationship between entropy and evil in terms of metaphor. After presenting the various meanings of entropy in classical thermodynamics and statical mechanics, and the Augustinian and Irenaean theodicies, several ...
doaj +2 more sources
Arrow of time and gravitational entropy in collapse
Classical and Quantum GravityAbstract We investigate the status of the gravitational arrow of time in the case of a spherical collapse of a fluid that conducts heat and radiates energy. In particular, we examine the results obtained by W. B. Bonnor in his 1985 paper where he found that the gravitational arrow of time was opposite to the thermodynamic arrow of time ...
Samarjit Chakraborty +3 more
openaire +3 more sources
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
New Journal of Physics, 2016 We postulate a principle stating that the initial condition of a physical system is typically algorithmically independent of the dynamical law. We discuss the implications of this principle and argue that they link thermodynamics and causal inference. On
Dominik Janzing +2 more
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Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Cancer biomarker discovery: the entropic hallmark. [PDF]
PLoS ONE, 2010 BACKGROUND: It is a commonly accepted belief that cancer cells modify their transcriptional state during the progression of the disease. We propose that the progression of cancer cells towards malignant phenotypes can be efficiently tracked using high ...
Regina Berretta, Pablo Moscato
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Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source