Results 71 to 80 of about 71,617 (299)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

A quantum solution to the arrow-of-time dilemma [PDF]

, 2008
The arrow of time dilemma: the laws of physics are invariant for time inversion, whereas the familiar phenomena we see everyday are not (i.e. entropy increases).
A. Peres, D. Z. Albert, D. Z. Albert, E. Borel, E. P. Gyftopoulos, F. Reif, H. Price, H. D. Zeh, J. Loschmidt, L. Szilard, L. S. Schulman, Lorenzo Maccone, P. C. W. Davies, R. Landauer, R. Penrose, T. Gold, W. H. Zurek   +16 more
core   +2 more sources

Time arrow without past hypothesis: a toy model explanation

New Journal of Physics
The laws of Physics are time-reversible, making no qualitative distinction between the past and the future—yet we can only go towards the future. This apparent contradiction is known as the ‘arrow of time problem’.
Pablo Arrighi, Gilles Dowek, Amélia Durbec   +2 more
doaj   +1 more source

Entropy Derived from Causality

Entropy, 2020
The second law of thermodynamics, with its positive change of entropy for a system not in equilibrium, defines an arrow of time. Interestingly, also, causality, which is the connection between a cause and an effect, requests a direction of time by ...
Roland Riek
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Irreversibility and the arrow of time in a quenched quantum system [PDF]

, 2015
Irreversibility is one of the most intriguing concepts in physics. While microscopic physical laws are perfectly reversible, macroscopic average behavior has a preferred direction of time. According to the second law of thermodynamics, this arrow of time
Batalhao, T. B., Lutz, E., Oliveira, I. S., Paternostro, M., Sarthour, R. S., Serra, R. M., Souza, A. M.   +6 more
core   +2 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Quantum Theory of Irreversibility

, 2005
A generalization of the Gibbs-von Neumann relative entropy is proposed based on the quantum BBGKY [Bogolyubov-Born-Green-Kirkwood-Yvon] hierarchy as the nonequilibrium entropy for an N-body system.
A. Pérez-Madrid, Bedeaux, Boercker, Bogoliubov, de Groot, Dorfman, Pérez-Madrid, Reguera, Rondoni, Schlöglm, van Kampen, Vollmer, von Neumann, Wehrl, Zwanzig   +14 more
core   +2 more sources

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Fisher's arrow of `time' in cosmological coherent phase space

, 1998
Fisher's arrow of `time' in a cosmological phase space defined as in quantum optics (i.e., whose points are coherent states) is introduced as follows. Assuming that the phase space evolution of the universe starts from an initial squeezed cosmological ...
B. ROY FRIEDEN, Frieden B. R., Gasperini M., Grishchuk L., Grishchuk L. P., H. C. ROSU, Plastino A. R., Rothman T., Winitzki S., Zel’dovich Ya. B.   +9 more
core   +1 more source