Results 211 to 220 of about 3,082,804 (300)

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Influence of coriolis force and nanoparticle aggregation on entropy generation and thermal conductivity in dusty nanofluid flow: a numerical investigation. [PDF]

Sci Rep
Ali B, Hussain M, Awan AU, Ahammad NA, Gamaoun F, Gusu DM, Nadeem S.   +6 more
europepmc   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Impact of Magnetohydrodynamics on Thermal Mixing Efficiency and Entropy Generation Analysis Passing Through a Micromixer Using Non-Newtonian Nanofluid. [PDF]

Micromachines (Basel)
Tayeb NT, Laouid YAA, Lakhdar A, Mostefa T, Kim SM, Hossain S.   +5 more
europepmc   +1 more source

Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells

FEBS Open Bio, EarlyView.
Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley   +1 more source

Thermodynamic process of entropy generation and MHD convection in porous cavity saturated with MWCNT-Fe₃O₄/H₂O hybrid nanofluid: Darcy-Forchheimer-Brinkmann model. [PDF]

Discov Nano
Hussain SM, Abdelkader A, Redouane F, Rachid H, Mohammed A, Guedri K, Eid MR, Ahmad H, Bayram M, Qureshi MA.   +9 more
europepmc   +1 more source

A nationwide student survey on biochemistry learning resources in Italy

FEBS Open Bio, EarlyView.
We conducted a survey among Italian university students to investigate their preferred study materials for biochemistry. We then analyzed the collected data to identify these materials. This information may be valuable to the Biochemistry educational community. The graphical abstract was created with Claude (Opus 5.5; Anthropic, 2026).
Anna Marabotti, Ivano Eberini, Maria Luisa Genova, Francesca Mensitieri, Francesco Malatesta   +4 more
wiley   +1 more source

Computational analysis of entropy generation in EMHD micropolar dusty fluid flow incorporating esterification process. [PDF]

Sci Rep
Awan AU, Hussain M, Ali B, Ahammad NA, Gamaoun F, Kafle J, Nadeem S.   +6 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Entropy Generation Optimization in Multidomain Systems: A Generalized Gouy-Stodola Theorem and Optimal Control. [PDF]

Entropy (Basel)
Richter H, Fathizadeh M, Kaptain T.
europepmc   +1 more source