Results 121 to 130 of about 7,508 (293)

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

Multi-objective optimization of microporous heat exchangers: A sensitivity analysis and response surface methodology

Case Studies in Thermal Engineering
This study presents a multi-objective optimization framework for microporous heat exchangers (MCHXs) using Lattice Boltzmann Method (LBM) simulations and Response Surface Methodology (RSM).
Mokhtar Ferhi, Ridha Djebali
doaj   +1 more source

Entropy Generation Minimization and Heat Transfer Enhancement for CSP Systems

, 2023
Advancements in clean, inexhaustible energy technologies remove humanity’s reliance on fossil fuels which are an unsustainable resource. Solar energy, unlike other forms of renewables, has a consistent source of energy, the sun.
Haddad, Fouad
core  

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

A filter-less LES model based on the local minimization of the entropy generation rate: model description

, 2022
The paper discusses a novel LES turbulent model, first presented in a linearized version in 2019. The model, named “ESS-LES” (for Entropy Smoothing at Sub-grid-scales LES), is based on the local minimization of the entropy generation rate in each single ...
Sciubba E., Zullo F.
core  

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Entropy generation analysis as a design tool - A review

, 2014
There is an acknowledged growing need for efficient and sustainable systems that use available energy resources in an “optimal” (including constraints) way.
Sciacovelli, Adriano, Sciubba, E., Verda, Vittorio, SCIUBBA, Enrico   +3 more
core   +1 more source

Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Despite its monogenic origin, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy exhibits marked variability in clinical expression and severity. Variants in the NOTCH3 gene, within epidermal growth factor‐like repeat domains 1–6 or 7–34, are known to influence disease onset, but their impact ...
Léa Aguilhon, Hugues Chabriat, Dominique Hervé, Stéphanie Guey, Sophie Tezenas Du Montcel, Juliette Ortholand   +5 more
wiley   +1 more source

Optimal design of vertical ground heat exchangers by using entropy generation minimization method and genetic algorithms

, 2014
This paper presents the development and validation of an optimal design methodology for vertical U-tube ground heat exchangers (GHEs) used in HVAC systems. The dimensionless entropy generation number obtained by scaling the entropy generation due to heat
Su HUANG (20125053), Zhenjun Ma (19585240), Paul Cooper (19585999)   +2 more
core  

Screening Routine Clinical Notes for Epilepsy Surgery Candidates Using Large Language Models

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy surgery is severely underutilized despite proven efficacy, with substantial under‐referral of eligible patients in routine clinical practice. This study evaluated the potential role of large language models (LLMs) as decision‐support tools for screening unstructured clinical notes to identify epilepsy surgery candidates and ...
Uriel Fennig, Nadav Amir, Maya Schiller, Roni Loebenstein, Johnatan Nissan, Marina Boxer, Shany Guly Gofrit, Gal Goshen, Sándor Beniczky, Nicola Maggio   +9 more
wiley   +1 more source