Results 221 to 230 of about 118,745,644 (290)

Structural Phylogenetic Signal Fails at Deep Time: A Bayesian Treebank Analysis of the Transeurasian Languages. [PDF]

Entropy (Basel)
Li W, Liu H.
europepmc   +1 more source

Trafficking Deficiency of TMEM175 Variants in Parkinson's Disease Pathogenesis and the Prospects of Precision Medicine

Advanced Science, EarlyView.
This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo, Yu He, Shuyao Li, Haoyu Guan, Ruili Cui, Yu Shi, Zhongwen Jiang, Siyu Wang, Xuan Li, Jiyuan Li, Mei Hu, Yupeng Zhou, Beisha Tang, Yanyan Zhang, Zhaobing Gao, Yu Zhou, Zhenhua Liu, Ping Li   +17 more
wiley   +1 more source

Inheritance entropy: A model-independent method to probe the hereditary structure of cell lineage trees. [PDF]

PRX Life
Allegrezza A, Beschi R, Caudo D, Cavagna A, Corsi A, Culla A, Donsante S, Giannicola G, Giardina I, Gosti G, Grigera TS, Melillo S, Palmisano B, Parisi L, Postiglione L, Riminucci M, Rotondi FS.   +16 more
europepmc   +1 more source

Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States

Advanced Science, EarlyView.
Manipulation of intranuclear divalent cation concentrations rapidly and reversibly remodels chromatin packing domains in living cells. Magnesium depletion disrupts domain compaction, heterochromatin organization, and transcriptional regulation, whereas magnesium loading promotes more compact and stable domains.
Cody L. Dunton, Carrillo Paola Gonzalez, Luay Almassalha, Wing Shun Li, Ruyi Gong, Nicolas Acosta, I Chae Ye, Jane Frederick, Christopher Hogg, Saira John, J. A. Gareth Williams, Rikkert J. Nap, Igal Szleifer, Vadim Backman   +13 more
wiley   +1 more source

s_mmpbsa: A Lite and Cross-Platform MM-PBSA Program. [PDF]

Molecules
Zhang J, Gu T, Li C, Qi W.
europepmc   +1 more source

Tied to Work: Topologically Knotted SPOUT Methyltransferases and UCH Deubiquitinases in Cellular Biochemistry. [PDF]

J Cell Biochem
Hsu SD.
europepmc   +1 more source

Substrate Engineering of SWCNT p–n Junctions for Dual‐Mode Power Generation and Heat‐Flux Sensing

Advanced Science, EarlyView.
Through substrate engineering alone, a single‐walled carbon nanotube p–n junction device switches between two functions under uniform infrared irradiation. A low‐absorbance substrate sustains a central hot junction for continuous power generation, whereas high‐absorbance substrates transiently invert the temperature gradient for sensitive heat‐flux ...
Ryota Tamai, Hiroto Nakayama, Shuya Ochiai, Masayuki Takashiri   +3 more
wiley   +1 more source

TGDBN: Topology-guided dual-backbone network for semi-supervised blastocyst segmentation in assisted reproductive technology. [PDF]

PLoS One
Li Y, Wang H, Hu J, Zhang J.
europepmc   +1 more source

Physics‐Aware Machine‐Learning‐Driven Inverse Design of Broadband Ultra‐Open Acoustic Metamaterials

Advanced Science, EarlyView.
A physics‐aware machine‐learning framework enables inverse design of ultra‐open acoustic silencers by decoupling spectral and radial design spaces. The approach rapidly identifies broadband, compact, and highly ventilated architectures, while revealing hidden linear design rules that link geometry, impedance matching, and acoustic performance.
Zhiwei Yang, Mengyu Li, Xiaohang Xie, Ao Chen, Thomas G. Bifano, Xin Zhang   +5 more
wiley   +1 more source

Objective Multi-Metric Fusion for Critical Node Identification via CRITIC and Global-Local Context Modeling. [PDF]

Entropy (Basel)
Cai P, Lu C, Huang Y, Xie Y.
europepmc   +1 more source