Results 61 to 70 of about 203,140 (213)

Primary and secondary prevention of cerebrovascular diseases in young people: an application for individually wearable gadgets as an element of the medical decision-making system

Лечащий Врач
Background. Cerebrovascular disorders are a real tragedy on a global scale. The number of cases of acute cerebral circulatory disorders of this type reaches 400-450 thousand per year.
T. I. Dutova, I. N. Banin, N. A. Ermolenko, Yu. V. Lyutikov, V. O. Lavrenteva   +4 more
doaj   +1 more source

Improved detection of paroxysmal atrial fibrillation utilizing a software-assisted electrocardiogram approach.

PLoS ONE, 2014
BackgroundAutomated complexity-based statistical stroke risk analysis (SRA) of electrocardiogram (ECG) recordings can be used to estimate the risk of paroxysmal atrial fibrillation (pAF).
Jürgen R Schaefer, Dieter Leussler, Ludger Rosin, David Pittrow, Thomas Hepp   +4 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Investigation of Outbreaks of Viral Hemorrhagic Septicemia and Associated Risk Factors in Rainbow Trout Farms in Iran, 2014

مجله اپیدمیولوژی ایران, 2017
Background and Objectives: In Iran, rainbow trout farms exist in almost all provinces. Viral hemorrhagic septicemia is one of the most important infectious diseases of the rainbow trout which is a serious threat to the farming industry.
S Bokaei, K Absalanfard, MH Fallah Mehrabadi, H Ebrahimzadeh Mosavi, A Ghajari, N Shahbazian   +5 more
doaj  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Transition to Kindergarten: Negative Associations between the Emotional Availability in Mother–Child Relationships and Elevated Cortisol Levels in Children with an Immigrant Background

Frontiers in Psychology, 2017
Background: The transition to child care is a challenging time in a child’s life and leads to elevated levels of cortisol. These elevations may be influenced by the quality of the mother–child relationship.
Constanze Rickmeyer, Judith Lebiger-Vogel, Marianne Leuzinger-Bohleber   +2 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Global cardiovascular risk assessment by family physicians in Suez canal university-family medicine centers-Egypt

Journal of Family Medicine and Primary Care, 2013
Background: The close sustained contact of family physician with their patients and local community makes preventive care an integral part of their routine work. Most cardiovascular diseases (CVD) can be prevented by addressing their risk factors.
Hebatallah Nour-Eldein, Shimaa A Abdelsalam, Gamila M Nasr, Hassan A Abdelwahed   +3 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Association between strategies to prevent COVID-19 infection in long-term care facilities and mortality: the PIANO-COVID-19 study, a French multicentre cohort study

BMJ Public Health
Objective Evidence for the effectiveness of strategies that aimed to prevent COVID-19 infection on reducing mortality in long-term care facilities (LTCFs) is limited. Our aim was to investigate the association between strategies aimed at preventing COVID-
Sandrine Andrieu, Olivier Hanon, Galdric Orvoën, Olivier Guerin, Gaetan Gavazzi, Hubert Blain, Claire Roubaud-Baudron, Yves Rolland, Delphine Pennetier, Jason Shourick, Philipe de Souto Barreto, Céline Mathieu, Cecile Balandier, Sylvie Bonin-Guillaume, Gael Durel, Vincent Guion, Claude Jeandel, Laure Jouatel, Nathalie Maubourguet, Yves Passadori, Axel Renoux, Claude Roussillon Soyer, Nathalie Salles, Maturin Tabué-Teguo, Helene Villars   +24 more
doaj   +1 more source