Results 111 to 120 of about 391,750 (316)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

TWO RECURSIVELY ENUMERABLE SETS OF INCOMPARABLE DEGREES OF UNSOLVABILITY (SOLUTION OF POST'S PROBLEM, 1944) [PDF]

, 1957
R. Friedberg
openalex   +1 more source

Quantum weight enumerators [PDF]

IEEE Transactions on Information Theory, 1998
In a recent paper ([quant-ph/9610040]), Shor and Laflamme define two ``weight enumerators'' for quantum error correcting codes, connected by a MacWilliams transform, and use them to give a linear-programming bound for quantum codes. We introduce two new enumerators which, while much less powerful at producing bounds, are useful tools nonetheless.
openaire   +5 more sources

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

Using Volunteer Computing to Study Some Features of Diagonal Latin Squares

Open Engineering, 2017
In this research, the study concerns around several features of diagonal Latin squares (DLSs) of small order. Authors of the study suggest an algorithm for computing minimal and maximal numbers of transversals of DLSs.
Vatutin Eduard, Zaikin Oleg, Kochemazov Stepan, Valyaev Sergey   +3 more
doaj   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Classes of recursively enumerable sets and their decision problems [PDF]

, 1953
H. G. Rice
openalex   +1 more source

Mechanisms and kinetic assays of aminoacyl‐tRNA synthetases

FEBS Letters, EarlyView.
Igor Zivkovic, Morana Dulic, Ita Gruic‐Sovulj   +2 more
wiley   +1 more source

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

Enumerating Alternating Trees

Journal of Combinatorial Theory, Series A, 2001
A tree \(T_n\) with \(n\) labelled nodes is said to be an alternating tree if the labels of the nodes on every path form an alternating sequence. \textit{A. Postnikov} [J. Comb. Theory, Ser. A 79, No. 2, 360-366 (1997; Zbl 0876.05042)] used generating functions and Lagrange's inversion formula to derive an expression for the number of unrooted ...
Chauve, Cedric, Dulucq, Serge, Rechnitzer, Andrew   +2 more
openaire   +4 more sources