Results 281 to 290 of about 307,376 (353)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Nonattainability of the Fragility Index. [PDF]

Cureus
Heston TF.
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Spatial Resampling Obscures Temporal Change in Malaria Prevalence: Evidence from Simulated Malaria Indicator Surveys

Kamwezi R, Mategula D, Chipeta MG, Stanton M.   +3 more
europepmc   +1 more source

Integrating AI in Medicinal Chemistry for Accelerated Drug Discovery: A Comprehensive SAR (CSAR) Optimization Strategy and Discovery of Potent ALDH3A1 Inhibitors. [PDF]

J Med Chem
Jain S, Yasgar A, Dalal A, Nilova A, Davies M, Baljinnyam B, Qu Y, Denson JP, Esposito D, Tao D, Yang SM, Talley DC, Simeonov A, Martinez NJ, Rai G, Zakharov AV.   +15 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A multimodal single-cell framework for ecosystem-level profiling of circulating tumor and non-tumor cells. [PDF]

Exp Hematol Oncol
Felix G, Aguirre F, Zhou L, Denmark A, Alvarez R, Kim DM, Gong J, Hitchins MP.   +7 more
europepmc   +1 more source

African Crop Calendar: A geo-referenced dataset of crop growing seasons across diverse agro-ecological regions. [PDF]

Sci Data
Waha K, Rötzer S, De Vos K, Grewer U, Tomes A, Mechiche-Alami A.   +5 more
europepmc   +1 more source

Two-Stage Sequential Fermentation of Oat Drink Using <i>Saccharomyces boulardii</i> and <i>Lactiplantibacillus plantarum</i>: A Promising Strategy for Developing Paraprobiotic-Probiotic Food. [PDF]

Food Sci Nutr
Babolanimogadam N, Gandomi H, Basti AA, Taherzadeh MJ, Ahadzadeh S, Alhashem SHS, Farzaneh M.   +6 more
europepmc   +1 more source

Hematogones in CD34+ leukapheresis units: Is it important to quantify and report them? [PDF]

Hematol Transfus Cell Ther
Albuquerque RB, da Silva HL, Duarte FB, Matos DM.   +3 more
europepmc   +1 more source