Results 21 to 30 of about 2,482 (203)

Apriorics: Information and Graphs in the Description of the Fundamental Particles—A Mathematical Proof

open access: yesMathematics
In our earlier work, we suggested an axiomatic framework for deducing the fundamental entities which constitute the building block of the elementary particles in physics. The basic concept of this theory, named apriorics, is the ontological structure (OS)
Yakir Shoshani, Asher Yahalom
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

Spectral Graph Compression in Deploying Recommender Algorithms on Quantum Simulators

open access: yesComputers
This follow-up scientific case study builds on prior research to explore the computational challenges of applying quantum algorithms to financial asset management, focusing specifically on solving the graph-cut problem for investment recommendation ...
Chenxi Liu   +2 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Split-and-Reduce: A New Exact Algorithm with Tight Multi-Order Intersection Bounds for the Quasi-Clique Enumeration Problem

open access: yesMathematics
The quasi-clique enumeration problem (degree-based quasi-cliques) is substantially more challenging than the classical clique problem because quasi-cliques do not satisfy the hereditary property, leading to exponential search spaces even in dense graphs.
Liang Li
doaj   +1 more source

Synthesis of Processing Systems Taking into Account Reliability

open access: yesChemical Engineering Transactions, 2018
Reliability is one of the most important properties of processing systems because of its high level direct effect on the investment and operational costs.
Akos Orosz   +2 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Twin Subgraphs and Core-Semiperiphery-Periphery Structures

open access: yesComplexity, 2018
A standard approach to reduce the complexity of very large networks is to group together sets of nodes into clusters according to some criterion which reflects certain structural properties of the network.
Ricardo Riaza
doaj   +1 more source

Topology of matching complexes of complete graphs via discrete Morse theory [PDF]

open access: yesDiscrete Mathematics & Theoretical Computer Science
Bouc (1992) first studied the topological properties of $M_n$, the matching complex of the complete graph of order $n$, in connection with Brown complexes and Quillen complexes. Bj\"{o}rner et al. (1994) showed that $M_n$ is homotopically $(\nu_n-1)$
Anupam Mondal   +2 more
doaj   +1 more source

Home - About - Disclaimer - Privacy