Results 111 to 120 of about 26,662,906 (359)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Controlled environment life support system: Growth studies with potatoes [PDF]

Results of experiments conducted to maximize the productivity of potatoes grown under controlled environmental conditions are discussed. A variety of parameters is examined which affect potato growth, specifically, photoperiod, light intensity ...
Tibbitts, T. W., Wheeler, R. M.
core   +1 more source

Instruction sequences for the production of processes [PDF]

, 2008
Single-pass instruction sequences under execution are considered to produce behaviours to be controlled by some execution environment. Threads as considered in thread algebra model such behaviours: upon each action performed by a thread, a reply from its
C. A. Middelburg, C. A. Middelburg, C. A. Middelburg, J. A. Bergstra, J. A. Bergstra, J. A. Bergstra   +5 more
core   +4 more sources

Specific biomarkers and neurons distribution of different brain regions in largemouth bass (Micropterus salmoides)

Frontiers in Endocrinology
The brain regulates multiple physiological processes in fish. Despite this, knowledge about the basic structure and function of distinct brain regions in non-model fish species remains limited due to their diversity and the scarcity of common biomarkers.
Meijia Li, Leshan Yang, Leshan Yang, Lei Zhang, Lei Zhang, Qian Zhang, Qian Zhang, Ying Liu, Ying Liu   +8 more
doaj   +1 more source

Usability, occupational performance and satisfaction evaluation of a smart environment controlled by infrared oculography by people with severe motor disabilities. [PDF]

PLoS One, 2021
Sime MM, Bissoli ALC, Lavino-Júnior D, Bastos-Filho TF.   +3 more
europepmc   +1 more source

Procedure to prepare transparent silica gels [PDF]

, 1987
This invention relates to the production of silica gels and in particular to a process for the preparation of silica gels which can be used as a crystal growth medium that simulates the convectionless environment of space to produce structurally perfect ...
Barber, Patrick G., Simpson, Norman R.
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Copper exposure causes alteration in the intestinal microbiota and metabolites in Takifugu rubripes

Ecotoxicology and Environmental Safety
Copper is an environmental pollutant, and copper in aquatic environments mainly comes from soil and water. It enters the environment through atmospheric deposition, sewage discharge, and industrial production, and enters aquatic organisms, causing ...
Pengfei Liu, Yanyun Liu, Jianxin Cheng, Yuqing Xia, Yi Yang   +4 more
doaj   +1 more source