Results 211 to 220 of about 26,662,906 (359)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

The role of simulation-based assessments in bridging the gap between theory and practice in medical education. [PDF]

J Educ Health Promot
Dorle AA, Borkar A, Bankar NJ, Badge AK, Tiwade YR.   +4 more
europepmc   +1 more source

Waste heat use in a controlled environment greenhouse [PDF]

Burns, E. R., Madewell, C. E., Pile, R. S.   +2 more
core   +1 more source

Controlling the environment

Materials Today, 2003
openaire   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Virtual reality in treatment of psychological disorders: a systematic review. [PDF]

Front Digit Health
Ghorayeb J, Kalahasthi R, Hosseini-Kamkar N.   +2 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Hydrogels-Advanced Polymer Platforms for Drug Delivery. [PDF]

Polymers (Basel)
Ene Vatcu R, Iacob AT, Fulga I, Di Gioia ML, Dragostin I, Fulga A, Samal SK, Dragostin OM.   +7 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Continuing industrial emissions are delaying the recovery of the stratospheric ozone layer. [PDF]

Nat Commun
Reimann S, Western LM, Lickley MJ, Sherry D, Daniel JS, Kuijpers LJM, Montzka SA, Rigby M, Velders GJM, Vollmer MK, Emmenegger L, Liang Q, Park S, Solomon S.   +13 more
europepmc   +1 more source