Results 91 to 100 of about 3,733,652 (265)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Florea: Jurnal Biologi dan Pembelajarannya, 2018 With regard to the environment, waste has a wide impact such as environmental pollution. Development of monitoring in terms of pengelolahan and conservation of river ecosystems needs to be done, the habit of disposing waste disposable diapers is ...
Angsoka Dwipayana Marthaliakirana
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
HEAVY METAL ANALYSIS IN WASTE WATER SAMPLES FROM VALEA ŞESEI TAILING POND [PDF]
Aerul şi Apa: Componente ale Mediului, 2011 Heavy metal analysis in waste water samples from Valea Şesei tailing pond. The mining of ore deposits and the processing and smelting of copper at Roşia Poieni have resulted in an increase of the toxic elements concentration within all components of the ...
I. L. MELENTI, E. MAGYAR, T. RUSU
doaj
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Reciclagem química de zeólitas comerciais desativadas
Química Nova, 2004 Pyro and hydrometallurgical processes were applied to the treatment of spent commercial zeolites (a molecular sieve and a ZSM-5 sample). Both catalysts were employed in pilot plant units.
Afonso Júlio Carlos +4 more
doaj
Measures of galaxy environment - I. What is ‘environment’?
, 2011 The influence of a galaxy's environment on its evolution has been studied and compared extensively in the literature, although differing techniques are often used to define environment. Most methods fall into two broad groups: those that use nearest neighbours to probe the underlying density field and those that use fixed apertures.
Muldrew, Stuart I. +21 more
openaire +4 more sources