Results 121 to 130 of about 10,830,821 (340)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Zero trust in edge computing environment: a blockchain based practical scheme
, 2022 Dawei Li +3 more
openalex +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
AN ECONOMETRIC PERSPECTIVE ON PUBLIC ENVIRONMENTAL CAPITAL FORMATION AND INDUSTRIAL EMISSIONS: EVIDENCE FROM SEVEN EU COUNTRIES [PDF]
Global Economic ObserverThis paper investigates the dynamics and relationship between greenhouse gas emissions from industrial processes and product use (GHG), and general government expenditures on environmental protection in gross fixed capital formation (GFCF).
GEORGE-CORNEL DUMITRESCU
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Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Designing a goal-oriented smart-home environment [PDF]
, 2016 Javier Palanca +5 more
openalex +1 more source
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Andromeda: a peptide search engine integrated into the MaxQuant environment.
Journal of Proteome Research, 2011 J. Cox +5 more
semanticscholar +1 more source
Editors’ Introduction for NANO Special Issue 13: The Anthropocene
NANO, 2018 What does it mean, then, to be human—even a human environmentalist—on a planet imperiled by our presence? That question underlies this special issue of NANO on the Anthropocene through three articles and two critical interviews.
Kyle Wiggins and Brandon Krieg
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