Results 61 to 70 of about 709,002 (300)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Environmental consciousness and moral hazard in international agreements to protect the environment [PDF]

open access: yesJournal of Public Economics, 1996
A group of countries that can potentially commit to cooperation to protect the environment are identified as environmentally-conscious countries. Conditions are examined under which they can provide self-financing side payments, to a second group of less environmentally-conscious countries, so that the two groups form a global or partial stable ...
Petrakis, Emmanuel   +1 more
openaire   +2 more sources

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Evolution of Representations and Intersubjectivity as sources of the Self. An Introduction to the Nature of Self-Consciousness. [PDF]

open access: yes, 2006
It is agreed by most people that self-consciousness is the result of an evolutionary process, and that representations may have played an important role in that process.
Menant, Christophe
core  

Mind and Brain States [PDF]

open access: yes, 2015
With neurons emergence, life alters itself in a remarkable way. This embodied neurons become carriers of signals, and processing devices: it begins an inexorable progression of functional complexity, from increasingly drawn behaviors to the mind and ...
Hipólito, Inês
core   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

open access: yesFEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu   +10 more
wiley   +1 more source

“It was not Death” : The Poetic Career of the Chronotope [PDF]

open access: yes, 2010
As Bakhtin noted, chronotopes arise from the density and fusion of temporal and spatial indicators. In prose narrative, the density of temporal and spatial indicators arises as a natural consequence of setting scenes and explaining action, and those ...
Ladin, Joy
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

The role of family in creating the ecological consciousness at children [PDF]

open access: yesSinteze, 2017
Family as a community of parents and children has a great role in forming the ecological consciousness of children. It is the first social environment with witch child make contact, and it depends a lot of family what social habits child is going to ...
Marković Mirjana M.
doaj   +1 more source

Supraconscious [PDF]

open access: yes, 2017
This paper tries to identify the missing link in between human consciousness and unconsciousness processes as precursors of self-development. Further through boundless and countless holistic representation to reality projecting upon the worst ...
Rizvi, Syed Ismyl Mahmood
core  

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