Results 111 to 120 of about 25,414,586 (332)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Ethical Principles in AI Use for Assessment: Exploring Students’ Perspectives on Ethical Principles in Academic Publishing

Education Sciences
Students’ comprehension of ethical principles and their application in the realm of AI technology play a crucial role in shaping the efficacy and morality of assessment procedures.
Alexandra Maria Lazăr (Cățeanu), Angela Repanovici, Daniela Popa, Diana Geanina Ionas, Ada Ioana Dobrescu   +4 more
doaj   +1 more source

Studying in an innovative teaching-learning environment: design-based education at a university of applied sciences. [PDF]

Learn Environ Res, 2023
Geitz G, Donker A, Parpala A.
europepmc   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Biophilic Design Applications: Putting Theory and Patterns into Built Environment Practice

, 2017
In 1984 E.O. Wilson (1984) introduced and popularized the Biophilia hypothesis defining biophilia as "the urge to affiliate with other forms of life" (Kellert & Wilson 1995: 416).
P. Downton, David Jones, Joshua Zeunert, Phillip Roös   +3 more
semanticscholar   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Passive Design of Buildings for Extreme Weather Environment

, 2013
Buildings account for nearly 40% of the end-use energy consumption and carbon emissions globally. Buildings, once built, are used at least for several decades.
R., Tokpatayeva, S., Tokbolat, S.N., Al-Zubaidy   +2 more
core  

Toward sustainable construction 3D printing: limestone and non-calcined recycled marine clay as partial cement replacement

Cleaner Engineering and Technology
This study investigates the effects of partial substitution of Ordinary Portland Cement with different proportions of non-calcined marine clay and different grades (by particle size) of Ground Limestone to formulate 3D-printable concrete.
Harn Wei Kua, Anqi Shi, Vignesh Kajandran, Charlene, Tiam Weng Mark Lam, Abhimanyu Goel, De Hui Alwin Wong, Peak Kee Lim, Layla Harris Kasee, Xi Wen Ong, Ghasan Fahem Huseien, Alexander Lin   +11 more
doaj   +1 more source

Retracted: Public Art and Space Environment Design Using Genetic Algorithm-Guided 3D Virtual Reconstruction. [PDF]

J Environ Public Health, 2023
Environmental And Public Health JO.
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source