Results 111 to 120 of about 1,704,273 (267)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Built Environment Design and People with Autism Spectrum Disorder (ASD): A Scoping Review. [PDF]

Int J Environ Res Public Health, 2021
Tola G, Talu V, Congiu T, Bain P, Lindert J.   +4 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Experimental Study of Local Scour Around Two Compound Piles in Tandem, Side-by-Side and Staggered Arrangements Under Steady Current

Journal of Marine Science and Engineering
Scour around two compound piles (CPs) in tandem, side-by-side (SBS), and staggered arrangements is investigated through experiments. Each CP has a larger diameter foundation, which is partially buried, and a smaller diameter top part with a diameter ...
Muhammad Adnan, Ming Zhao, Helen Wu, Adnan Munir, Vatsal Dhamelia   +4 more
doaj   +1 more source

Understanding Home Activities Challenges of Older Adults Aging with Long-term Mobility Disabilities: Recommendations for Home Environment Design. [PDF]

J Aging Environ, 2022
Ramadhani WA, Rogers WA.
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Comparative Analysis of Balanced Maintenance System and Scheduled Maintenance System for Urban Rail Transit Vehicle

Chengshi guidao jiaotong yanjiu
[Objective] In order to reduce the purchase cost and operation and maintenance cost of urban rail transit vehicles as much as possible, balanced maintenance system is adopted in some cities in China.
Tao HUANG, Zhengyuan ZHANG, Shixi SHI
doaj   +1 more source

The Application of Color Psychology in Community Health Environment Design.

J Environ Public Health, 2022
Yang J, Shen X.
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source