Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
The psychological impact of COVID-19 quarantine on children, and the role of parental support and physical environment design. [PDF]
Discov Psychol, 2021 Aljunaidy MM, Adi MN.
europepmc +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
From footway design to the street environment: removing the barriers to walking [PDF]
, 2009 7-9 October ...
Achuthan, K, Mackett, RL, Titheridge, H
core
Church pipe organs: historical tuning records as indoor environmental evidence
Buildings & CitiesChurches are increasingly challenged to balance rising thermal comfort expectations with the microclimatic requirements for conserving heritage artefacts.
Bruno Bingley +2 more
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Understanding Home Activities Challenges of Older Adults Aging with Long-term Mobility Disabilities: Recommendations for Home Environment Design. [PDF]
J Aging Environ, 2022 Ramadhani WA, Rogers WA.
europepmc +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Review of computer vision in intelligent environment design [PDF]
This paper discusses and compares the use of vision based and non-vision based technologies in developing intelligent environments. By reviewing the related projects that use vision based techniques in intelligent environment design, the achieved ...
Lin, Chenghua, Liu, Kecheng, Wei, Hong
core
Software test automation : a design and tool selection approach for a heterogeneous environment [PDF]
, 2013 textThis report describes a design approach for implementing a software test automation solution that can accommodate existing test processes in an organization.
Azrai, Iyad Shaher
core +1 more source