Results 71 to 80 of about 3,129,923 (288)
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Fields of Fuel: Market and Environmental Implications of Switching to Grass for U.S. Transport [PDF]
, 2010 Analyzes how increased commercial switchgrass production for biofuel affects land use, commodity prices, and the environment. Suggests policy actions on research, carbon impact estimates, mitigation payments, and air, soil, and water quality ...
Liz Marshall, Zachary Sugg
core
Postfledging Survival, Movements, and Dispersal of Ring Ouzels (Turdus torquatus) [PDF]
, 2013 We thank Invercauld Estate for cooperation with access to Glen Clunie. S. Redpath, J. Wilson, and S. Roos provided valuable comments on the manuscript. This study was funded by the Royal Society for the Protection of Birds, Scottish Natural Heritage, and
Eaton M. A. +10 more
core +1 more source
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Reasons and control measures for viscous bulking of activated sludge in A2O process
Gongye shui chuliSludge viscosity expansion has always been a difficulty in the operation control of A2O process. The sludge viscosity expansion problem occurred in a sewage treatment plant in Zhengzhou City, resulting in poor sludge settling performance with SVI ...
ZHAO Xiaojuan +3 more
doaj +1 more source
THE SUSTAINABLE DEVELOPMENT – A GREEN INVESTMENT ARGUMENT [PDF]
Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2013 Man has always tried to model nature since ancient times, but at the same time, he had to follow certainrules for living in harmony with it and do not affect its renewal cycle.
MAFTEI DANIEL
doaj
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Modelling landscape controls on dissolved organic carbon sources and fluxes to streams [PDF]
, 2014 Acknowledgments We thank the Natural Environment Research Council NERC (project NE/K000268/1) for funding. Iain Malcolm and staff at Marine Scotland (Pitlochry) are also thanked for the provision of data from the AWS as are the Scottish Environmental ...
Birkel, C. +3 more
core +2 more sources