Results 101 to 110 of about 3,026,929 (303)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
What Triggers Environmental Management and Innovation? – Empirical Evidence for Germany [PDF]
It is frequently hypothesized that environmental management systems (EMSs) may improve a firm’s environmental performance. Whether or not this hypothesis is true is as important from the perspective of environmental policy as questions relating to the ...
Jens Horbach +2 more
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Consumer Car Preferences and Information Search Channels [PDF]
In this paper, we measure the relations between stated and revealed car preferences and the use of information sources in the car purchasing process, based on a survey of households in the Netherlands.
Frank J. van Rijnsoever +2 more
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
The Determinants of Environmental Awareness and Behavior [PDF]
This paper investigates the determinants of environmental values across countries. Its purpose is to put the role of economic affluence into perspective by challenging the conventional wisdom that states that the level of economic affluence influences ...
Quentin M. Duroy
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EcosphereEresus kollari is typically found in dry grasslands and stony steppes; however, in South Korea, it has been primarily found in the humid environments of cemeteries.
Jin Hyeok Choi +3 more
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
, 2003 The purpose of this resource is to observe budburst on selected trees at a Land Cover or Phenology Site. All students will learn about hummingbird natural history and ecology.
The GLOBE Program, University Corporation for Atmospheric Research (UCAR)
core
Environmental Participation and Environmental Motivation [PDF]
We explore whether environmental motivation affects environmental behavior by focusing on volunteering. The paper first introduces a theoretical model of volunteering in environmental organizations.
Alison Macintyre +2 more
core +3 more sources