Results 141 to 150 of about 12,123,041 (353)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Environmental tobacco smoke risk perception and smoking behavior in Portugal [PDF]
This study analyzes public attitudes towards environmental tobacco smoking (ETS) risks. ETS legislation and smoking behaviors using recent data from Special Eurobarometer 272 that is a unique database on public perception of ETS.
Anabela Botelho +3 more
core
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Endogenous Fiscal Policies, Environmental Quality, and Status-Seeking Behavior. [PDF]
This paper analyzes endogenous fiscal policy and public decision in an endogenous growth model where agents care about social status and environmental quality. The quest for a higher status is assimilated to a preference for capital wealth.
Phu NGUYEN-VAN, Thi Kim Cuong PHAM
core
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Prediction of Middle School Students’ Recycling Behaviors with Machine Learning Algorithms
Science Education InternationalRecycling waste is essential to mitigate environmental damage caused by human activity. Environmentally responsible behaviors, shaped during early ages, are closely linked to environmental attitudes, as demonstrated by prior research.
Fatma Merve Mustafaoğlu, Fatma Alkan
doaj +1 more source
Environmental and Pro-Social Norms: Evidence from 30 Countries [PDF]
The paper investigates the relationship between pro-social norms and its implications for improved environmental outcomes, an area which has been neglected in the environmental economics literature.
Benno Torgler +2 more
core
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
A Community-Based Accommodation Program for Adults with Autism and Mental Retardation [PDF]
, 2009 There is a paucity of treatment literature for significant and intractable behavior problems in adults with autism and mental retardation. Four adults with autism, severe to profound mental retardation, and serious, long-term behavior problems ...
Fox, Robert A. +2 more
core +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source