Results 91 to 100 of about 21,977,854 (330)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Individualism, Environmentalism and Social Change [PDF]

, 2012
Market logic encourages the idea everything can be bought and sold, and in effect creates an individualized society. This individualization affects consumption habits, environmental action, and social change.
Chelstowski, Alex
core   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Plant macrofossil data for 48-0 ka in the USGS North American Packrat Midden Database, version 5.0

Scientific Data
Plant macrofossils from packrat (Neotoma spp.) middens provide direct evidence of past vegetation changes in arid regions of North America. Here we describe the newest version (version 5.0) of the U.S.
Laura E. Strickland, Robert S. Thompson, Sarah L. Shafer, Patrick J. Bartlein, Richard T. Pelltier, Katherine H. Anderson, R. Randall Schumann, Andrew K. McFadden   +7 more
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Residential retrofit in the climate emergency: the role of metrics

Buildings & Cities, 2020
This paper examines whether current residential retrofit metrics are fit for purpose and if they can help deliver swift and significant cuts in carbon emissions. Information is presented on metrics used for a variety of UK and European Union building and
Tina Fawcett, Marina Topouzi
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Using herbaria to study global environmental change

New Phytologist, 2018
Summary During the last centuries, humans have transformed global ecosystems. With their temporal dimension, herbaria provide the otherwise scarce long‐term data crucial for tracking ecological and evolutionary changes over this period of intense global ...
Patricia L. M. Lang, F. Willems, J. F. Scheepens, H. Burbano, O. Bossdorf   +4 more
semanticscholar   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Should Environmental Ethicists Fear Moral Anti-Realism? [PDF]

, 2019
Environmental ethicists have been arguing for decades that swift action to protect our natural environment is morally paramount, and that our concern for the environment should go beyond its importance for human welfare.
Rubin, Michael, Schwenkenbecher, Anne
core   +1 more source