National perspectives on climate change adaptation: A panel discussion of climate change adaptation efforts in diverse coastal regions of the United States [PDF]
, 2010 Climate change has rapidly emerged as a significant threat to coastal areas around the world. While uncertainty regarding distribution, intensity, and timescale inhibits our ability to accurately forecast potential impacts, it is widely accepted that ...
Bohlander, Andy +3 more
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A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
ICT and the Environment in Developing Countries: an Overview of Opportunities and Developments [PDF]
Both developed and developing countries face many environmental challenges, including climate change, improving energy efficiency and waste management, addressing air pollution, water quality and scarcity, and loss of natural habitats and biodiversity ...
John HOUGHTON
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Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Sustainable Approaches in Built Environment in Preparing for Global Environmental Change [PDF]
, 2014 No ...
DOLA, KAMARIAH, Pour Rahimian, Farzad
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Tracking Environmental Change Using Lake Sediments: Data Handling and Numerical Techniques
, 2001 J. Smol
semanticscholar +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Fearless: Gettysburg\u27s Environmental Concerns Organization (GECO)
, 2014 Gettysburg’s Environmental Concerns Organization (GECO) fearlessly advocates for environmental change, promotes awareness and encourages better sustainability practices on our campus, and the world around us.
Bassler, Chrisitina L.
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Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
RWU to Lead Effort to Create Environmental Impact Against Climate Change [PDF]
, 2016 U.S. Senator Sheldon Whitehouse to issue a call to action on climate change and launch a student-led Conservation Corps at Roger Williams University on March ...
Curtis, Lynda
core +1 more source