Results 191 to 200 of about 21,977,854 (330)

Distributive impact of structural change: does environmental degradation matter? [PDF]

Vulnerability to reduction of natural capital depends on defensive substitution possibilities that, in turn, are affected by the availability of other productive factors.
Angelo Antoci, Elisa Ticci, Paolo Russu
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Hormesis as a Hidden Hand in Global Environmental Change? [PDF]

Environ Sci Technol
Rillig MC, Lehmann A, Bi M.
europepmc   +1 more source

Explaining international co-authorship in global environmental change research [PDF]

This paper maps the domain of earth and environmental sciences (EES) and investigates the relationship between cognitive problem structures and internationalisation patterns, drawing on the concepts of systemic versus cumulative global environmental ...
Jappe-Heinze, Arlette
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Early Oldowan technology thrived during Pliocene environmental change in the Turkana Basin, Kenya. [PDF]

Nat Commun
Braun DR, Palcu Rolier DV, Advokaat EL, Archer W, Baraki NG, Biernat MD, Beaudoin E, Behrensmeyer AK, Bobe R, Elmes K, Forrest F, Hammond AS, Jovane L, Kinyanjui RN, de Martini AP, Mason PRD, McGrosky A, Munga J, Ndiema EK, Patterson DB, Reeves JS, Roman DC, Sier MJ, Srivastava P, Tuosto K, Uno KT, Villaseñor A, Wynn JG, Harris JWK, Carvalho S.   +29 more
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Heat Tolerance in Older Adults: A Systematic Review of Thermoregulation, Vulnerability, Environmental Change, and Health Outcomes. [PDF]

Healthcare (Basel)
Núñez-Rodríguez S, Collazo-Riobó C, Sedano J, Sánchez-Iglesias AI, González-Santos J.   +4 more
europepmc   +1 more source

Mountain lakes: Eyes on global environmental change

Global and Planetary Change, 2019
K. Moser, J. Baron, J. Brahney, I. Oleksy, J. Saros, E. J. Hundey, S. Sadro, J. Kopáček, R. Sommaruga, M. Kainz, A. Strecker, S. Chandra, D. Walters, D. Preston, N. Michelutti, F. Lepori, S. Spaulding, K. Christianson, J. Melack, J. Smol   +19 more
semanticscholar   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source