Results 111 to 120 of about 1,418,768 (341)

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Open questions on the environmental chemistry of radionuclides. [PDF]

Commun Chem, 2020
Deblonde GJ, Kersting AB, Zavarin M.
europepmc   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Environmental chemistry is most relevant to study coronavirus pandemics. [PDF]

Environ Chem Lett, 2020
Sharma VK, Jinadatha C, Lichtfouse E.
europepmc   +1 more source

Replication Data for: Variation in Phenolic Chemistry in Zostera marina Seagrass along Environmental Gradients

, 2020
Cecilie Sævdal Dybsland, Kjersti Hasle Enerstvedt, Monica Jordheim   +2 more
openalex   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

The Physics of Detonation Chemistry: A Radical Theory in Predicting the Deflagration to Detonation Transition and Environmental Explosions [PDF]

, 2021
V. R. Sanal Kumar, Nichith Chandrasekaran, Vigneshwaran Sankar, Ajith Sukumaran, Sivabalan Mani, Tharikaa Ramesh kumar, Sathyan Padmanabhan, Vignesh Saravanan, Vishnu Natarajan, Hema Sai Nagaraju Doddi, Mohammed Niyasdeen Nejaamtheen, Sulthan Ariff Rahman Mohamed Rafic, Roshan Vignesh Baskaran, Pavithra Murugesh, Amrith Mariappan, Thianesh U.K, Anand Moorthi, Mohan Elumalai, Pradeep Kumar Pavalavanni, Rajaghatta Sundararam Bharath, Charlie Oommen, Pradeep Kumar Radhakrishnan, Shiv Kumar Choudhary   +22 more
openalex   +1 more source

Secondary Organic Aerosol Formation from Healthy and Aphid-Stressed Scots Pine Emissions. [PDF]

, 2019
One barrier to predicting biogenic secondary organic aerosol (SOA) formation in a changing climate can be attributed to the complex nature of plant volatile emissions.
Buchholz, Angela, Faiola, Celia L, Holopainen, Jarmo K, Kari, Eetu, Khalaj, Farzaneh, Kivimäenpää, Minna, Miettinen, Pasi, Pullinen, Iida, Schobesberger, Siegfried, Virtanen, Annele, Yli-Juuti, Taina, Ylisirniö, Arttu   +11 more
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source