Results 141 to 150 of about 7,263,430 (296)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Liposome-water and octanol-water partitioning of alcohol ethoxylates

, 1999
Haitzer M, Burnison BK, Hoess S, Traunspurger W, Steinberg C. Effects of quantity, quality, and contact time of dissolved organic matter on bioconcentration of benzo[a]pyrene in the nematode, Caenorhabditis elegans. Environmental Chemistry and Toxicology.
Preston, S., Escher, BI, Plans, M., Clarke, KR, Steinberg, CEW, Scheper, B.B., Leonards, P.E.G., Cofino, W.P., Traunspurger, Walter, Stronkhorst, J., Hoss, S, Burnison, B.K., Prow, Tarl, Tronczynski, J., Sanderson, T., Pignatello, Joseph J., Vermeulen, N.P.E., Knight, B., McGrath, S. P., Ratte, Hans Toni, de Haas, E., Wim P. Cofino, Thomas, Kevin V., Muller, MT, Chasteen, Thomas G., Paton, G. I., Brinkman, U.A.T., Bleeker, E.A.J., Patel, Shiv J., Steinberg, C., Albanis, T.A., Boyd, Elaine M., Chambers, Susan M., Killham, K., Thompson, Ian P., Watson, John, Meharg, Andrew A.; id_orcid, Admiraal, W., Haitzer, M., Greve, G.D., Stuijfzand, S.C., Alexander, Martin, Commandeur, J.N.M., Cairney, John W G, Vooijs, R., Thain, John E., Damia Barceló, White, Jason C., Fisher, Nicholas S., van Hattum, A.G.M., Van Fleet-Stalder, Verena, Udo A. Th. Brinkman, Leslie, H.A., Schat, H., Sharma, S.S., Liles, Nathan, Groenendijk, D., Pim E. G. Leonards, Vermeulen, N.P.E.; id_orcid, Dickerson, Sarah, Maguire, Nicola, Barceló, D., Bowmer, C.T., Sailer, Brian L., Zehnder, AJB, Hans Toni Ratte, Haitzer, M, Sharples, Jade M., Kraak, M.H.S., Vooijs, H., Wang, Wen Xiong, Jacek Tronczynski, Augustijn, C., Bailey, Mark J., Waldock, Michael J., Ruud J. C. A. Steen, van Wezel, A., Hoess, S., Steen, R.J.C.A., Hunter, Margaret, Triantafyllos A. Albanis, Ellis, Richard J., Leonards, P.E.G.; id_orcid, van der Geest, H.G., Nam, Kyoungphile, van Heerwaarden, L.M., Urzelai, Arantzazu, Angulo, Eduardo, Chowdhury, M.J., Vega, Milagrosa M., van Ginneken, L., Blust, R.   +91 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

The CompTox Chemistry Dashboard: a community data resource for environmental chemistry. [PDF]

J Cheminform, 2017
Williams AJ, Grulke CM, Edwards J, McEachran AD, Mansouri K, Baker NC, Patlewicz G, Shah I, Wambaugh JF, Judson RS, Richard AM.   +10 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Leveraging Interfacial Electric Field for Smart Modulation of Electrode Surface in Nitrate to Ammonia Conversion

Advanced Science
The efficiency of nitrate reduction reaction (NO3RR) at low nitrate concentration is predominantly hindered by the poor affinity of nitrate ions and competitive hydrogen evolution reaction (HER), particularly in neutral and acidic media.
Kouer Zhang, Yifan Xu, Fatang Liu, Qing Wang, Xiaohong Zou, Mingcong Tang, Michael K.H. Leung, Zhimin Ao, Xunhua Zhao, Xiao Zhang, Liang An   +10 more
doaj   +1 more source