Results 111 to 120 of about 330,119 (322)

Size‐Modulated Mesoderm‐Endoderm Divergence and Myocardial Cavitation in Micropatterned Cardioids

Advanced Science, EarlyView.
Micropatterned cardioids, CRISPR‐engineered reporter hiPSCs, deep‐tissue imaging, and single‐cell RNA sequencing are integrated to model mesoderm‐endoderm co‐development. Heart‐foregut crosstalk promotes single large cavitation inside cardioids, resembling early heart chamber formation. ABSTRACT The human heart, originating from the splanchnic mesoderm,
Plansky Hoang, David W. McKellar, Andrew Kowalczewski, Nhu Y. Mai, Meng Chai, Xiaojun L. Lian, Yi Zheng, Jeffrey Amack, Nathan Tucker, Iwijn De Vlaminck, Huaxiao Yang, Benjamin D. Cosgrove, Zhen Ma   +12 more
wiley   +1 more source

Spatiotemporal Calibration of Atmospheric Nitrogen Dioxide Concentration Estimates From an Air Quality Model for Connecticut

, 2019
A spatiotemporal calibration and resolution refinement model was fitted to calibrate nitrogen dioxide (NO$_2$) concentration estimates from the Community Multiscale Air Quality (CMAQ) model, using two sources of observed data on NO$_2$ that differed in ...
Gilani, Owais, Gregoire, Timothy G., Guan, Yongtao, Holford, Theodore R., Leaderer, Brian P., McKay, Lisa A.   +5 more
core   +1 more source

GNL3 Orchestrates AR Transcriptional Programs to Drive Castration‐Resistant Prostate Cancer and Immune Evasion

Advanced Science, EarlyView.
GNL3 is a novel AR coregulator with dual coactivator and corepressor functions in prostate cancer (PCa). Our study uncovers a previously unrecognized mechanism by which the AR transcriptional complex integrates oncogenic signaling and immune suppression.
Cuiting Zhang, Tin Long Cheong, Nitin Narwade, Dandan Dong, Mokan Deng, Zhengqiang Miao, Zhaoqiang Ding, Wenchao Li, Kate Man Kei Lei, Gong‐Hong Wei, Terence Chuen Wai Poon, Chu‐Xia Deng, Edwin Cheung   +12 more
wiley   +1 more source

A matter of scale: Identifying the best spatial and temporal scale of environmental variables to model the distribution of a small cetacean

Ecology and Evolution
The importance of scale when investigating ecological patterns and processes is recognised across many species. In marine ecosystems, the processes that drive species distribution have a hierarchical structure over multiple nested spatial and temporal ...
Tiffany Goh, Mark Jessopp, Emer Rogan, Enrico Pirotta   +3 more
doaj   +1 more source

Assessing the Role of Environmental Covariates and Pixel Size in Soil Property Prediction: A Comparative Study of Various Areas in Southwest Iran

Land
(1) Background: The use of multiscale prediction or the optimal scaling of predictors can enhance soil maps by applying pixel size in digital soil mapping (DSM).
Pegah Khosravani, Majid Baghernejad, Ruhollah Taghizadeh-Mehrjardi, Seyed Roohollah Mousavi, Ali Akbar Moosavi, Seyed Rashid Fallah Shamsi, Hadi Shokati, Ndiye M. Kebonye, Thomas Scholten   +8 more
doaj   +1 more source

On the effect of preferential sampling in spatial prediction

, 2012
The choice of the sampling locations in a spatial network is often guided by practical demands. In particular, many locations are preferentially chosen to capture high values of a response, for example, air pollution levels in environmental monitoring ...
Banerjee, Banerjee, Chakraborty, Cocchi, Cressie, Dawid, Diggle, Diggle, Hooten, Illian, Latimer, Lee, Lewis, Müller, Nychka, Pati, Pilz, Sahu, Sahu, Sheppard, Theobald, Xia   +21 more
core   +1 more source

Alternating High‐Fat and Polysaccharide Diets Modulates Gut Phage‐Bacterial Interplay

Advanced Science, EarlyView.
This study reveals how alternating high‐fat and polysaccharide diets reshape the human gut virome and enhance phage‐bacteria interactions. Using large‐scale metagenomic meta‐analysis and a time‐resolved mouse model, the authors show that diets strongly modulate phage abundance, lifestyle, and gene exchange, offering new insights into nutrition‐guided ...
Fengxiang Zhao, Ruiqi Zhang, Rujun Wei, Huimin Fan, Yongfei Hu, Wenyu Shi, Jinfeng Wang   +6 more
wiley   +1 more source

Maternal Preconception Antibiotic Exposure Disrupts Microbial Succession: A Transgenerational Risk for Offspring Gut Mucosal Immaturity and Colitis Susceptibility

Advanced Science, EarlyView.
This study reveals that maternal antibiotic exposure prior to conception disrupts intergenerational gut microbial succession. By enhancing maternal‐offspring microbial transmission, altering microbial developmental trajectories and increasing selective pressures during community assembly, these disturbances lead to persistent gut mucosal immaturity and
Yuzhu Chen, Ruqiao Duan, Cunzheng Zhang, Gaonan Li, XiaoLin Ji, Qi Zhang, Fei Pei, Kun Wang, Liping Duan   +8 more
wiley   +1 more source

Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk

Advanced Science, EarlyView.
Integration of a pancreatic eQTL map with a GWAS meta‐analysis identifies 82 putative functional variants and 15 genes. The association between rs11102484 and pancreatic cancer risk is observed in a total of 5699 cases and 8467 controls. The G allele of rs11102484 weakens ZNF263 binding and the silencer‐promoter interaction, thereby increasing ST7L ...
Xiaoyang Wang, Hui Geng, Zhengyan Yao, Yuan Jiang, Can Chen, Zequn Lu, Shuangshuang Tian, Ming Zhang, Ruiyan Liu, Chenxi Feng, Bin Li, Xiaoping Miao, Jianbo Tian, Shaokai Zhang, Ying Zhu   +14 more
wiley   +1 more source

Prediction of soil texture using remote sensing data. A systematic review

Frontiers in Remote Sensing
Soil particle size fractions play a critical role in determining soil health attributes, including soil aeration, water infiltration and retention capacity, nutrients, and organic matter dynamics.
R. N. Mgohele, R. N. Mgohele, B. H. J. Massawe, M. J. Shitindi, H. G. Sanga, M. M. Omar, M. M. Omar   +6 more
doaj   +1 more source