Genetic and environmental influences on covariation in reproducible diet–metabolite associations
The American Journal of Clinical Nutrition, 2021Early applications of metabolomics in nutrition and health research identified associations between dietary patterns and metabolomic profiles. Twin studies show that diet-related phenotypes and diet-associated metabolites are influenced by genes.
Kate M Bermingham +7 more
openaire +2 more sources
Sex steroids at birth: Genetic and environmental variation and covariation
Developmental Psychobiology, 1991AbstractThree sex‐steroids (estradiol, progesterone, & testosterone) were assayed from the umbilical cord blood of 58 same‐sex twin pairs in an investigation of the effects of sex, as well as genetic and environmental factors, on neonatal hormone levels.
L M, Sakai +3 more
openaire +2 more sources
Analysis of Spatial Covariance Structure for Environmental Data
2005Formulation and evaluation of environmental policy depend upon a general class of latent variable models known as multivariate receptor models. Estimation of the number of pollution sources, the source composition profiles and the source contributions are the main interests in multivariate receptor modelling.
A. Lamberti, NISSI, Eugenia
openaire +2 more sources
Model-driven development of covariances for spatiotemporal environmental health assessment
Environmental Monitoring and Assessment, 2012Known conceptual and technical limitations of mainstream environmental health data analysis have directed research to new avenues. The goal is to deal more efficiently with the inherent uncertainty and composite space-time heterogeneity of key attributes, account for multi-sourced knowledge bases (health models, survey data, empirical relationships etc.
Alexander, Kolovos +5 more
openaire +2 more sources
Cormack–Jolly–Seber model with environmental covariates: A P‐spline approach
Biometrical Journal, 2012In capture–recapture models, survival and capture probabilities can be modelled as functions of time‐varying covariates, such as temperature or rainfall. The Cormack–Jolly–Seber (CJS) model allows for flexible modelling of these covariates; however, the functional relationship may not be linear.
Stoklosa, Jakub, Huggins, Richard M.
openaire +3 more sources
Distribution and variance/covariance structure of pesticide environmental fate data
Environmental Toxicology and Chemistry, 2008Abstract Hydrophobicity, persistence, and volatility data for individual pesticides are widely used in risk assessment and transport modeling, so it is important to understand their distribution, variation, and covariation. Correlations (normalized covariance) among properties across a range of multiple pesticides are also important for ...
openaire +2 more sources
MAXIMUM VARIANCE LINEAR COMBINATIONS FROM PHENOTYPIC, GENETIC, AND ENVIRONMENTAL COVARIANCE MATRICES
Multivariate Behavioral Research, 1970Vectors of weights derived from principal components analysis of stan- dardized phenotypic, genetic, and environmental covariance matrices were applied to open-field behavioral scores from mice in order to obtain composite scores with maximum phenotypic (Vp), genetic (Va), and environmental (Ve)variance, respectively.
J P, Hegmann, J C, DeFries
openaire +2 more sources
Candidate‐gene association studies with pedigree data: Controlling for environmental covariates
Genetic Epidemiology, 2003AbstractCase‐control studies provide an important epidemiological tool to evaluate candidate genes. There are many different study designs available. We focus on a more recently proposed design, which we call a multiplex case‐control (MCC) design. This design compares allele frequencies between related cases, each of whom are sampled from multiplex ...
S L, Slager +3 more
openaire +2 more sources
Reduced Rank Covariances for the Analysis of Environmental Data
2011In this work we propose a Monte Carlo estimator for non stationary covariances of large incomplete lattice or irregularly distributed data. In particular, we propose a method called “reduced rank covariance” (RRC), based on the multiresolution approach for reducing the dimensionality of the spatial covariances.
Orietta Nicolis, Doug Nychka
openaire +1 more source
The spatial analysis of covariates in a study of environmental epidemiology
Statistics in Medicine, 1995AbstractKanawha County, West Virginia, includes a deep river valley with a large population living in close proximity to many chemical manufacturing centres. One study of this area combined an epidemiologic survey of children attending Kanawha County schools with the measurement of the concentrations of 15 volatile organic compounds at each of the 75 ...
openaire +2 more sources

