Results 151 to 160 of about 11,405,425 (350)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Crisis pregnancy counselling in Ireland

, 2004
Between September 2002 and September 2003 Dr. Saoirse Nic Gabhainn and Dr. Vivienne Batt of the Centre for Health Promotion Studies and the Women’s Studies Centre, National University of Ireland, Galway conducted research on behalf of the Crisis ...
Nic Gabhainn, Saoirse, Batt, Vivienne
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

OLYMPIC CRISIS, ENVIRONMENTAL CRISIS

Mercator, 2018
Gilmar MASCARENHAS, Leandro Dias de OLIVEIRA   +1 more
openaire   +2 more sources

Agricultural Crisis Mitigation Strategy through Scientific Interpretation: A Study on Tafsir Ilmi by the Indonesian Ministry of Religious Affairs

QOF
This research examines the scientific interpretation of agricultural verses in the Ministry of Religion’s interpretation. The Ministry of Religion’s scientific interpretation work responds to efforts to integrate science and the Qur’an.
Lukman Fajariyah, Mowafg Abrahem Masuwd
doaj   +1 more source

Bound by Infinities: Technology, Immediacy and Our Environmental Crisis. [PDF]

Am J Psychoanal, 2020
Melmed ML.
europepmc   +1 more source

Irish contraception and crisis pregnancy [ICCP] study: A survey of the general population

, 2004
Crisis pregnancy is a complex challenge for individuals and societies alike. Its prevention and management needs to be informed by up-to-date and locally applicable information on knowledge, attitudes and behaviours concerning sexual practices and ...
McGee, Hannah, Leigh, Collette, Rundle, Kay, Layte, Richard   +3 more
core  

Hizbollah and the Lebanese crisis / International Crisis Group

, 2007
Parallel als Buch-Ausg ...
unknown
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source