Results 121 to 130 of about 9,055,161 (340)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Microplastics mediated antibiotic resistance gene enrichment and transfer in environment: Different types, microplastic antibiotic resistance gene ecological island and nano-size effect

Ecotoxicology and Environmental Safety
Microplastics (MPs) and antibiotic resistance genes (ARGs) pose significant environmental threats. This review examines their interaction, highlighting MPs' role in ARGs accumulation and transport.
Baoxin Zhang, Yu Li, Zehua Zhao, Honghong Lyu, Lan Wang, Natalie Welden, Jingchun Tang   +6 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Hemifacial Microsomia with Spinal and Rib Anomalies: Prenatal Diagnosis and Postmortem Confirmation Using 3-D Computed Tomography Reconstruction

, 2011
Hemifacial microsomia (OMIM164210) is a condition featuring unilateral ear anomalies and ocular epibulbar dermoids associated with unilateral underdevelopment of the craniofacial bony structures.
Letizia Schreiber, Haratz, Karina Krajden [UNIFESP], Lev, Dorit, Gustavo Malinger, Vinkler, Chana, Dorit Lev, Schreiber, Letizia, Karina Haratz, Chana Vinkler, Malinger, Gustavo   +9 more
core   +1 more source

Strategies for Bovine Respiratory Disease (BRD) Diagnosis and Prognosis: A Comprehensive Overview

Animals
Simple Summary Bovine Respiratory Disease (BRD) poses a significant challenge in managing cattle health. This intricate disease affects both the upper and lower respiratory tracts in cattle and is influenced by various environmental, host, and microbial ...
M. Kamel, J. L. Davidson, M. S. Verma
semanticscholar   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

PCR analysis of the presence and location of Mycobacterium avium in a constructed reed bed, with implications for avian tuberculosis control

, 2009
The potential of reed beds to act as biofilters of pathogenic and environmental mycobacteria was investigated through examination of the fate of mycobacteria in a constructed reed bed filtering effluent from a large captive wildfowl collection ...
ZSL, Mwangi, D, Donoghue, H D, Wildfowl And Wetlands Trust, Cromie, RL, Drewe, JA, Donoghue, HD, Drewe, J A, Cromie, R L, UCL   +9 more
core   +1 more source

Port environmental management insights 2020

, 2021
This paper presents the results of research conducted in collaboration with 97 ESPO EcoPorts members that completed the Self-Diagnosis Method (SDM), most of them members of the EU TEN-T network.
Selén, Valter, Wooldridge, Chris, Darbra Roman, Rosa Maria, Puig Duran, Martí   +3 more
core   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source