Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Usefulness of environmental information to bank officers in Malaysia [PDF]
, 2015 Corporate social and environmental disclosure practices reflect corporate transparency and accountability towards wider stakeholders. Since information disclosure imposes huge costs upon companies, the usefulness of information to stakeholders is worth ...
Mohd Said, Ridzwana +2 more
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Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Pengaruh Ukuran Perusahaan, Tipe Industri, Profitabilitas, Leverage, dan Kinerja Lingkungan terhadap Environmental Disclosure (Studi Empiris Pada Perusahaan yang Terdaftar di BEI dan Menjadi Peserta PROPER Tahun 2011-2013) [PDF]
, 2015 The objective of this research is to analyze the influence of firm size, industry type, profitability, leverage, and enviromental performance on the level of Environmental Disclosure.
JULIARTO, Agung +1 more
core +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Scientific ReportsPresently, the driving factors for environmental regulatory intensity, especially environmental information disclosure, remain unclear. Exploring the causal relationship between the two has an important guiding value for governments to achieve ...
Yuzhuo Wang
doaj +1 more source
THE ROLE OF BIODIVERSITY DISCLOSURE IN SUSTAINABILITY REPORT ON FIRM VALUE [PDF]
, 2018 Companies in achieving their goals are likely to have an impact on the environment. Company operational activities directly affect the decline in the amount of biodiversity and indirectly contribute to climate change.
DESWITA, Shindy Sri, HARTO, Puji
core
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Jurnal Ekonomi Akuntansi dan Manajemen, 2015 This research was aimed to obtain empirical evidence about factors influencing environmental responsibility disclosure in the company`s annual report. The factors used in this research were profitability, company size, government regulation, corporate ...
Rochman Effendi +2 more
doaj
Pengaruh Pengelolaan Lingkungan dan Kepemilikan Institusional terhadap Corporate Social Responsibility Disclosure dengan Profitabilitas (Roa) Perusahaan sebagai Variabel Moderasi (Studi Empris pada Perusahaan Manufaktur yang Terdaftar di Bei [PDF]
, 2015 The purpose of this research is to determine the effect of environmental disclosure, institutional ownership toward corporate social responsibility disclosure (CSRD) with profitability (ROA) as a moderating variable.
Putri, S. R. (Suci) +2 more
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