Results 91 to 100 of about 15,273,122 (253)

Key technologies and environmental impact analysis of artificial island construction

open access: yesShenzhen Daxue xuebao. Ligong ban
Artificial island reclamation projects, as an important means of expanding land resources, have a dual impact on the ecological environment, potentially generating both positive benefits and environmental risks.
DONG Zijun   +6 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Environmental effect of smoking cessation. [PDF]

open access: yesCan Fam Physician, 2021
Green S, Davis M.
europepmc   +1 more source

Environmental effects of confined aquifer dewatering for cut and cover tunnels in floodplain areas of Yangtze River

open access: yesYantu gongcheng xuebao
Confined aquifer dewatering for cut and cover tunnels in the floodplain areas of Yangtze River characterized by complicated geological condition and high confined water level may result in considerable ground settlements, which may potentially cause ...
WANG Jun 1, LIU Songyu 2, ZHANG Xinyuan 1, XU Haiyuan 1, WANG Xiaoqiong 3, 4, LI Shilong 3, 4, SUN Yanxiao 2
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Environmental Outsourcing [PDF]

open access: yes
Recent years have witnessed a dramatic increase in the number of firms shifting stages of their production processes overseas. In this paper we investigate whether firms outsource the dirtier stages of production to minimise domestic environmental ...
Matthew A. COLE   +2 more
core  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

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