Results 41 to 50 of about 1,718,435 (261)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Exploring the potential mechanisms of anti-pulmonary fibrosis effects of Luo Han Guo via network pharmacology, molecular docking, and experimental validation

Scientific Reports
Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung condition distinguished by a complex etiology, poor prognosis and exhibiting high mortality rates.
Qinlin Cui, Yingyi Liu, Yuxuan Li, Zhan Li, Wencai Wei, Simei Yang, Xin Liu, Lei Chen, Kunyu Xu, Yihan Li, Qingbi Zhang, Jun Bai   +11 more
doaj   +1 more source

Intestine of invasive fish Prussian carp as a target organ in metal exposure assessment of the wastewater impacted freshwater ecosystem

Ecological Indicators, 2021
The application of invasive fish Prussian carp (Carassius gibelio Bloch, 1782) as bioindicator organism, using intestine as bioindicator tissue of anthropogenic influence in the lowland Ilova River was estimated.
Tatjana Mijošek, Vlatka Filipović Marijić, Zrinka Dragun, Dušica Ivanković, Nesrete Krasnići, Zuzana Redžović, Marijana Erk   +6 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

All that is silver is not toxic: silver ion and particle kinetics reveals the role of silver ion aging and dosimetry on the toxicity of silver nanoparticles

Particle and Fibre Toxicology, 2018
Background When suspended in cell culture medium, nano-objects composed of soluble metals such as silver can dissolve resulting in ion formation, altered particle properties (e.g. mass, morphology, etc.), and modulated cellular dose.
Jordan N. Smith, Dennis G. Thomas, Hadley Jolley, Vamsi K. Kodali, Matthew H. Littke, Prabhakaran Munusamy, Donald R. Baer, Matthew J. Gaffrey, Brian D. Thrall, Justin G. Teeguarden   +9 more
doaj   +1 more source

Flexible blanket synthetic aperture radar jamming using joint frequency and phase modulation

IET Radar, Sonar & Navigation, 2023
Synthetic Aperture Radar (SAR) jamming is of vital significance in the national defence aspect. In this study, a flexible blanket jamming method against SAR is proposed using joint frequency and phase modulation.
Qihua Wu, Xiaobin Liu, Zhiming Xu, Feng Zhao, Zhaoyu Gu, Shunping Xiao   +5 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

ADI-MRTD Algorithm for Periodic Structures Analysis

International Journal of Antennas and Propagation, 2018
In this paper, a novel algorithm based on the alternating direction implicit (ADI) multiresolution time-domain (MRTD) method for periodic structure simulation is proposed.
Xiaohua Dong, Yiwang Chen, Pin Zhang, Yichao Teng, Xiaobo Zhuansun   +4 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source