Results 121 to 130 of about 15,665,920 (290)

Metagenomic profiling of microbial community, antibiotic resistance genes and co-occurrence pattern in megacity rail transit system

Hygiene and Environmental Health Advances
Megacity rail transit systems harbor a pivotal microbial ecosystem that serves as a reservoir for antibiotic resistance genes (ARGs), which is intricately linked to the urban dissemination of infectious diseases. Here, we conducted metagenomic sequencing
Xiaojing Li, Lijun Zhang, Jian Chen
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Perfluorooctane sulfonate (PFOS) induced bone loss by inhibiting FoxO1-mediated defense against oxidative stress in osteoblast

Ecotoxicology and Environmental Safety
Exposure to perfluorooctane sulfonate (PFOS) has been associated with lower bone density and the occurrence of osteoporosis in human studies, but the effects and mechanisms of PFOS induces bone loss is not well understood.
Liming Xue, Jiale Xu, Ping Xiao, Yiping Jiang, Yuanjie Lin, Chao Feng, Yu’e Jin, Zhijun Zhou, Guoquan Wang, Dasheng Lu   +9 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Mechanism of Growth Phase-Dependent Nanoplastic Bioaccumulation in Tetrahymena thermophila

Antioxidants
Nanoplastics are ubiquitous in aquatic environments, and elucidating their bioaccumulation behavior is essential for assessing toxicity and trophic transfer risks.
Zhongquan Jiang, Tianyi Wei, Haipeng Tong, Ruikai Xing, Di Peng, Tao Yuan, Ling Zhao, Minghua Min, Wenbo Guo   +8 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Environmental Impact Assessment in the Bay of Bengal sub region in South Asia

, 2008
The environmental problems faced by the countries of the Bay of Bengal Sub region in South Asia (hereinafter the region) are significant but they are far from being managed in a sustainable manner.
Hassan, Daud, Hassan, D
core   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Feasibility of Using Remote-Sensing Techniques for Shoreline Delineation and Coastal Habitat Classification for Environmental Sensitivity Index (ESI) Mapping [PDF]

, 2005
Summary describing the work completed at Impact Assessment, Inc. for 'Environmental Sensitivity Index (ESI) Shoreline Classification Using New Remote Sensing Data and Techniques.' It includes background information on the project funding and sponsorship,
Impact Assessment, Inc.
core  

Air pollution might contribute to antimicrobial resistance: a One Health perspective

Science in One Health
Air pollution and antimicrobial resistance (AMR) are two critical challenges that threaten global health and sustainability. Emerging research suggests a significant connection between these phenomena, with air pollution potentially acting as a driver ...
Leshan Xiu, Shuangqing Hu
doaj   +1 more source