Results 121 to 130 of about 2,735,682 (296)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Perfluorooctane sulfonate (PFOS) induced bone loss by inhibiting FoxO1-mediated defense against oxidative stress in osteoblast

Ecotoxicology and Environmental Safety
Exposure to perfluorooctane sulfonate (PFOS) has been associated with lower bone density and the occurrence of osteoporosis in human studies, but the effects and mechanisms of PFOS induces bone loss is not well understood.
Liming Xue, Jiale Xu, Ping Xiao, Yiping Jiang, Yuanjie Lin, Chao Feng, Yu’e Jin, Zhijun Zhou, Guoquan Wang, Dasheng Lu   +9 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Mechanism of Growth Phase-Dependent Nanoplastic Bioaccumulation in Tetrahymena thermophila

Antioxidants
Nanoplastics are ubiquitous in aquatic environments, and elucidating their bioaccumulation behavior is essential for assessing toxicity and trophic transfer risks.
Zhongquan Jiang, Tianyi Wei, Haipeng Tong, Ruikai Xing, Di Peng, Tao Yuan, Ling Zhao, Minghua Min, Wenbo Guo   +8 more
doaj   +1 more source

Relationships between social forms of organic horticultural production and indicators of environmental quality: a multidimensional approach in Brazil [PDF]

, 2005
Organic farming (OF) is increasingly considered as a possible alternative for designing a "new rural" in Brazil, where OF covers a wide range of production and certification systems.
Bellon, Stéphane, Santiago de Abreu, Lucimar, Valarini, Pedro J.   +2 more
core  

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Environmental impact assessment of the pangasius sector in the Mekong Delta [PDF]

In the past seven years the export of white pangasius fillets grew fast. The culture method shifted to intensive production of striped catfish (Ca Tra) in deep ponds because this is more efficient than the pen and cage culture of Ca Basa.
Anh, P.T., Bosma, R.H., Dung, V.V., Fransen, M., Hanh, C.T.T., Hien, H.T.T., Hong, P.T.T., Minh, N.T., Phong, L.T., Potting, J., Tuan, T.T., Ut, V.N., Vuong, D.Q.T., Yen, T.   +13 more
core   +1 more source

Integrated building performance simulation [PDF]

, 2001
This paper justifies the need for an integrated approach to building performance assessment and provides examples of the technical appraisals that may then be enabled.
Clarke, J.A.
core  

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Air pollution might contribute to antimicrobial resistance: a One Health perspective

Science in One Health
Air pollution and antimicrobial resistance (AMR) are two critical challenges that threaten global health and sustainability. Emerging research suggests a significant connection between these phenomena, with air pollution potentially acting as a driver ...
Leshan Xiu, Shuangqing Hu
doaj   +1 more source