Results 131 to 140 of about 13,671,980 (384)

Geohazard Prevention Framework: Introducing a Cumulative Index in the Context of Management and Protection of Cultural and Natural Heritage Areas

Land
Geohazards pose an essential role to the preservation of cultural and natural heritage areas, given their valuable significance in terms of scenic, natural, and cultural characteristics, forming unique landscapes that require proactive action to achieve ...
George Faidon D. Papakonstantinou, Maria P. Papadopoulou   +1 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Unraveling ice multiplication in winter orographic clouds via in-situ observations, remote sensing and modeling

npj Climate and Atmospheric Science
Recent years have shown that secondary ice production (SIP) is ubiquitous, affecting all clouds from polar to tropical regions. SIP is not described well in models and may explain biases in warm mixed-phase cloud ice content and structure.
Paraskevi Georgakaki, Anne-Claire Billault-Roux, Romanos Foskinis, Kunfeng Gao, Georgia Sotiropoulou, Maria Gini, Satoshi Takahama, Konstantinos Eleftheriadis, Alexandros Papayannis, Alexis Berne, Athanasios Nenes   +10 more
doaj   +1 more source

An assessment of environmental impacts of cassava starch extraction technologies [PDF]

, 2011
The environmental impacts of the transformation of cassava roots into starch were assessed for three contrasting technologies at small and large scale (1-2 and 100-200t starch per day), using the Life Cycle Assessment (LCA) methodology. The objective was
Da, Guillaume, Dufour, Dominique, Giraldo Toro, Andres, Moreno, Martin A., Piyachomkwan, Kuakoon, Sriroth, Klanarong, Tran, Thierry, Velez, G.   +7 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Atmospheric Rivers Increase Future Flood Risk in Western Canada's Largest Pacific River

Geophysical Research Letters, 2019
Snow‐dominated watersheds are bellwethers of climate change. Hydroclimate projections in such basins often find reductions in annual peak runoff due to decreased snowpack under global warming. British Columbia's Fraser River Basin (FRB) is a large, nival
C. L. Curry, S. U. Islam, F. W. Zwiers, S. J. Déry   +3 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

RaFSIP: Parameterizing Ice Multiplication in Models Using a Machine Learning Approach

Journal of Advances in Modeling Earth Systems
Accurately representing mixed‐phase clouds (MPCs) in global climate models (GCMs) is critical for capturing climate sensitivity and Arctic amplification.
Paraskevi Georgakaki, Athanasios Nenes
doaj   +1 more source

Opening the Black Box: The Impacts of Environmental Regulations on Technological Innovation [PDF]

, 2020
Muyao Li, Jinsong Zhang, Ramakrishnan Ramanathan, Ruiqian Li   +3 more
openalex   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source