Results 51 to 60 of about 5,623,796 (340)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Unveiling Landscape‐Level Drivers of Freshwater Biodiversity Dynamics

Environmental DNA
Human activities severely impact biodiversity, particularly in freshwater lakes. These habitats provide critical ecosystem services and, at the same time, suffer from river inflow, agricultural runoff, and urban discharge.
Niamh Eastwood, Arron Watson, Jiarui Zhou, Luisa Orsini   +3 more
doaj   +1 more source

Green of Another Color: Building Effective Relationships Between Foundations and the Environmental Justice Movement [PDF]

, 2001
The aim of this report is to help forge more effective partnerships between and within the environmental justice movement and the philanthropic community.
Daniel Faber, Deborah McCarthy
core  

Intergenerational justice of what: welfare, resources or capabilities? [PDF]

, 2007
An important aspect of intergenerational justice concerns the specification of a 'currency of advantage' that can be used to evaluate distributive outcomes across time.
Arrow K. J., Barry B., Barry B., Baxter B., Brighouse H., Chambers N., Dworkin R., Edward A. Page, Kaufman A., McCarthy J. J., McMichael A. J., Nussbaum M., Nussbaum M., Page T., Rawls J., Rawls J., Sen A., Sen A., Sen A., Silver L. M., Sumner L. W., Wackernagel M.   +21 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

(In)justiça ambiental: uma proposta de modelo teórico-epistemológico

Desenvolvimento e Meio Ambiente, 2022
The process of reproduction of societies are marked by the confrontation between different projects of use and meaning of its environmental resources. It is under this aspect is that social actors committed the search for environmental justice seek to ...
Pollyana Martins Santos, Maria das Dores Saraiva de Loreto, Marcelo Leles Romarco de Oliveira   +2 more
doaj   +1 more source

Just transition: Integrating climate, energy and environmental justice

Energy Policy, 2018
Just transition is a new framework of analysis that brings together climate, energy and environmental justice scholarships. It was originally coined as a term that was designed to link the promotion of clean technology with the assurance of green jobs ...
D. McCauley, R. Heffron
semanticscholar   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Unravelling nature's values in EU agricultural policy: A critical discourse analysis

People and Nature
Agriculture plays a dual role as both a key driver and a potential solution for biodiversity loss. Farmers, holding a variety of values related to nature, are therefore key actors in biodiversity conservation.
Iven Froese, Lasse Loft
doaj   +1 more source