Results 41 to 50 of about 1,766,301 (307)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Private Options to Use Public Goods Exploiting Revealed Preferences to Estimate Environmental Benefits [PDF]

, 2003
We develop and apply a new method for estimating the economic benefits of an environmental amenity. The method fits within the household production framework (Becker 1965), and is based upon the notion of estimating the derived demand for a privately ...
Snyder, Lori D., Stavins, Robert N., Wagner, Alexander F.   +2 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Building the System: Follow-up, monitoring & adaptive management [PDF]

, 2020
Does impact assessment (IA) end when the license has been granted? While societal resources tend to focus on rigorous project approvals, what happens to the project, to the public and to the environment once approval is granted?
Fitzpatrick, Patricia, Williams, Byron
core  

Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error [PDF]

, 2016
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if ...
Amin, Najaf, Barathi, Veluchamy A, Bellenguez, Celine, Blettner, Maria, Boh, Eileen Tai-Hui, Burdon, Kathryn Penelope, Campbell, Harry, Consortium, Refractive Error and Myopia (CREAM), Cougnard-Gregoire, Audrey, Craig, Jamie E, Delcourt, Cecile, et. al., Evans, David M, Fan, Qiao, Fogarty, Rhys Daniel, Gharahkhani, Puya, Gieger, Christian, Guggenheim, Jeremy A, Guo, Xiaobo, Gupta, Preeti, Haller, Toomas, Hewitt, Alex W, Ho, Candice E H, Hofman, Albert, Hohn, Rene, Hosseini, S Mohsen, Huffman, Jenifer E, Hysi, Pirro, Igo, Robert P, Ikram, M Kamran, Joshi, Peter K, Kahonen, Mika, Khawaja, Anthony, Lehtimaki, Terho, Lim, Wan'e, Lu, Yi, Mazur, Johanna, McMahon, George, Meitinger, Thomas, Mirshahi, Alireza, Miyake, Masahiro, Pirastu, Mario, Polasek, Ozren, Portas, Laura, Raitakari, Olli, Ried, Janina S, Rivadeneira, Fernando, Rudan, Igor, Sabanayagam, Charumathi, Schwantes-An, Tae-Hwi, Seppala, Ilkka, Simpson, Claire L, St Pourcain, Beate, Tan, Vincent, Uitterlinden, Andre G, van Leeuwen, Elisabeth M, Vatavuk, Zoran, Venturini, Cristina, Verhoeven, Virginie J M, Vingerling, Johannes R, Vitart, Veronique, Wang, Xu, Wang, Ya Xing, Wedenoja, Juho, Williams, Katie M, Wilson, James F, Wojciechowski, Robert, Xie, Jing, Yamashiro, Kenji, Zeller, Tanja, Zhou, Lei   +70 more
core   +1 more source

ENVIRONMENTAL LICENSING:

, 2020
The National Environment Policy, established by Law No. 6938 of 1981, aims at environmental preservation in line with the economic and social development of the country, establishing, therefore, the appropriate guidelines and instruments. These include environmental impact assessment and environmental licensing of effective or potentially potentially ...
Mello, Marcela Souza Zarske de, Vieira, Ricardo Stanziola   +1 more
openaire   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Private Options to Use Public Goods Exploiting Revealed Preferences to Estimate Environmental Benefits [PDF]

We develop and apply a new method for estimating the economic benefits of an environmental amenity. The method fits within the household production framework (Becker 1965), and is based upon the notion of estimating the derived demand for a privately ...
Alexander F. Wagner, Lori D. Snyder, Robert N. Stavins   +2 more
core   +3 more sources

How green should environmental regulators be? [PDF]

, 2010
The extent to which environmental regulatory institutions are either 'green' or 'brown' impacts not just the intensity of regulation at any moment, but also the incentives for the development of new pollution-control technologies.
Heyes, A., Kapur, Sandeep
core  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source