Results 51 to 60 of about 14,869,790 (384)
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
HydrobiologyAn important top-down predator, the northern pike (Esox lucius), faces harsh environmental conditions in the northern boreal ecoregion. They are often managed for recreational fishing and, more recently, to create environmental offsets; strategies aimed ...
Sebastian Theis +4 more
doaj +1 more source
Unnes Law Journal, 2015 Kota Semarang sebagai kota industri dihadapi berbagai masalah pencemaran lingkungan. CV. Slamet Widodo bergerak di bidang pengolahan dan pembuatan terasi. Dalam prosesnya bau terasi tersebut mengakibatkan bau terasi yang begitu menyengat.
Harry Agung Ariefianto
doaj +1 more source
Ecological Solutions and Evidence, 2021 Human activities and development have contributed to declines in biodiversity across the globe. Understanding and addressing biodiversity loss will require the mobilization of diverse knowledge systems.
Dominique A. Henri +11 more
doaj +1 more source
International Journal of Energy Economics and Policy, 2019 Small and medium enterprises (SMEs) play a significant role in Indonesian business growth. Therefore, the objective of the present study is to investigate the association of antecedents of environmental management accounting and environmental performance
Azhar Susanto, Meiryani Meiryani
semanticscholar +1 more source
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
How does corporate management affect green innovation via business environmental strategies? [PDF]
, 2022 Sohail Ahmad Javeed +3 more
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source