Results 61 to 70 of about 14,869,790 (384)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Capim - gordura (Melinis minutiflora P. Beauv.), uma gramínea exótica que compromete a recuperação de áreas degradadas em unidades de conservação Molasses grass (Melinis minutiflora P. Beauv.), an exotic species compromising the recuperation of degraded areas in conservation units

Revista Árvore, 2004
O capim-gordura, Melinis minutiflora, é uma gramínea de origem africana que invade áreas degradadas da região do Cerrado em detrimento das espécies nativas.
Carlos Romero Martins, Laércio Leonel Leite, Mundayatan Haridasan   +2 more
doaj   +1 more source

Using perceptions as evidence to improve conservation and environmental management

Conservation Biology, 2016
The conservation community is increasingly focusing on the monitoring and evaluation of management, governance, ecological, and social considerations as part of a broader move toward adaptive management and evidence‐based conservation.
N. Bennett
semanticscholar   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

L’ancrage local des référentiels normatifs globaux : une approche en terme de réseaux

VertigO, 2005
The ISO 14001 standard is currently  the worldwide reference for Environmental Management System. For it has been produced at and for international level, how does it become embedded in local situations and  action context.This article highlights the ...
Nathalie Semal
doaj  

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Emprendedores y Empresas para el Siglo XXI. Responsabilidad Social y Medio Ambiente

Tec Empresarial, 2013
La actividad empresarial, más allá de su funciónexclusivamente económica, acaba afectando alconjunto de los ciudadanos por la existencia, entreotras, de las conocidas como externalidades, entrelas que se puede destacar el impacto sobre el medioambiente ...
Vicente Ramón Torcal Tomás
doaj  

Gestão ambiental integrada ao desenvolvimento sustentável: um estudo de caso em Passo Fundo (RS) Environmental management integrated with sustainable development: a case study in Passo Fundo, RS, Brazil

Revista de Administração Pública, 2006
A acelerada urbanização transforma espaços naturais e interfere no meio ambiente, apresentando resultados desastrosos tanto nos ecossistemas quanto na qualidade de vida das pessoas.
Adriana Marques Rossetto, Dora Maria Orth, Carlos Ricardo Rossetto   +2 more
doaj   +1 more source

Environmental management plan (EMP) [PDF]

, 2020
In order to achieve a target on resource conservation and pollution reduction thus Environmental Management Plan (EMP) was introduced. An EMP is a site or project specific plan developed to ensure that appropriate environmental management practices are
Abd Slam Alsonosi, AlShrif, Fadzil, Norzubaidah, Fettysha, Suhana, Othman, Nur Asmaliza, Zainol Abidin, Izzatul Ashikin, Zawani, Zuwairi Izwan   +5 more
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