Results 61 to 70 of about 14,719,621 (388)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Using perceptions as evidence to improve conservation and environmental management

open access: yesConservation Biology, 2016
The conservation community is increasingly focusing on the monitoring and evaluation of management, governance, ecological, and social considerations as part of a broader move toward adaptive management and evidence‐based conservation.
N. Bennett
semanticscholar   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

open access: yesMolecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad   +35 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

Capim - gordura (Melinis minutiflora P. Beauv.), uma gramínea exótica que compromete a recuperação de áreas degradadas em unidades de conservação Molasses grass (Melinis minutiflora P. Beauv.), an exotic species compromising the recuperation of degraded areas in conservation units

open access: yesRevista Árvore, 2004
O capim-gordura, Melinis minutiflora, é uma gramínea de origem africana que invade áreas degradadas da região do Cerrado em detrimento das espécies nativas.
Carlos Romero Martins   +2 more
doaj   +1 more source

Artificial intelligence and IoT driven technologies for environmental pollution monitoring and management

open access: yesFrontiers in Environmental Science
Detecting hazardous substances in the environment is crucial for protecting human wellbeing and ecosystems. As technology continues to advance, artificial intelligence (AI) has emerged as a promising tool for creating sensors that can effectively detect ...
S. M. Popescu   +10 more
semanticscholar   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Benefits in environment-related measures for company due to EMS implementation [PDF]

open access: yes, 2020
In the urban development, Environmental Management System (EMS) is known as a standardization of working system that thoroughly considered environmental improvement by the management of environmental data and information in the company. In line with that,
Abdul Kadir, Muhamad Nazmie   +4 more
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