Results 71 to 80 of about 4,189,438 (285)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Environmental Law, Governance, and Management- the Need for Environmental Management Systems for Cities [PDF]

, 2012
Human activities damage the environment. They deplete natural resources, generate pollution and wastes, accelerate the loss of forests and biological diversity, as well as threaten the water supply. As populations increase, these problems are exacerbated.
Lin Heng, Lye
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Implications of the New Constitution on Environmental Management in Kenya - Recent Development [PDF]

Law, Environment and Development Journal, 2012
The importance of anchoring environmental management in a country’s constitution cannot be over-emphasised. Kenya attained its independence from British colonial rule in 1963 but environmental management issues were not explicitly provided for in the ...
Angela Mwenda and Thomas N. Kibutu
doaj  

Ideal integrated national environmental management system for South Africa : a thesis presented in partial fulfilment of the requirements for the degree of Master of Philosophy in Development Studies at Massey University [PDF]

, 1995
The South African environmental management system has been characterised by fragmentation and the lack of effective legislation. The number of statutes concerned with conservation issues is an associated problem.
Utlwa, Abel Pheello
core  

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Environmental changes in Savannah's Area. Analysis o f causes and Use o f Soil to Relief. The case o f Araguari River Hydrographical Basin, MG

GEOUSP: Espaço e Tempo, 2002
This paper presents our reflections over the main geomorphological characteristics of the Araguari River Basin and offers an analysis about the changes done by man over the landscapes.
Sílvio Carlos Rodrigues
doaj   +1 more source

Solid waste management in Puerto Rico : an assessment of environmental impacts and benefits [PDF]

, 2011
Municipal solid waste (MSW) management has been a challenging issue throughout history. Waste management options have evolved, but they can present distinct environmental impacts, such as the emission of greenhouse gases (GHG).
Martinez-Colon, Jose F.
core