Results 41 to 50 of about 49,542 (203)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Fatores ambientais e risco de quedas em idosos: revisão sistemática

Revista Brasileira de Geriatria e Gerontologia
A queda em idosos é resultado de uma interação complexa entre fatores intrínsecos e extrínsecos. Embora seja difícil separar esses fatores, estudos apontam que fatores de risco ambientais estão presentes em aproximadamente 40% das quedas.
Adriana Sarmento de Oliveira, Patrícia Fernandes Trevizan, Maria Luisa Trindade Bestetti, Ruth Caldeira de Melo   +3 more
doaj   +1 more source

Did the elimination of lead from petrol reduce crime in the USA in the 1990s? [v2; ref status: indexed, http://f1000r.es/220]

F1000Research, 2013
This article assesses the evidence for the hypothesis that a decline in all types of crime since the early 1990s in the USA was a consequence of removing lead from petrol between 1975 and 1985.
Wayne Hall
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Environmental Medicine. [PDF]

Population Studies, 1975
J. W. B. Douglas, G. Melvyn Howe, John A. Loraine   +2 more
  +5 more sources

Fifteen Years of Health-and-Environment Research in Slovenia

Slovenian Journal of Public Health
The environment in which we are born, live, work, and age is an important determinant of human health. This review summarises key epidemiological studies conducted over the past 15 years at the Department of Public Health, Faculty of Medicine, University
Carli Tanja, Kukec Andreja, Zaletel-Kragelj Lijana, Eržen Ivan   +3 more
doaj   +1 more source

Physical environmental influences on human health

GMS Hygiene and Infection Control
This review examines physical environmental influences and their potential effect on human health. The factors discussed are noise (effect of sound), the physical effect of particulate matter (fine dust, particulate matter PM10, PM2.5, ultrafine ...
Katrin Steul, Sabine Meyer, Yanfeng Xue
doaj   +1 more source

Expert clinician’s perspectives on environmental medicine and toxicant assessment in clinical practice

Environmental Health and Preventive Medicine, 2018
Background Most clinicians feel ill-equipped to assess or educate patients about toxicant exposures, and it is unclear how expert environmental medicine clinicians assess these exposures or treat exposure-related conditions.
Nicole Bijlsma, Marc Maurice Cohen
doaj   +1 more source