Results 11 to 20 of about 5,439,350 (296)

Environmental contours for mixtures of distributions [PDF]

Proceedings of the 29th European Safety and Reliability Conference (ESREL), 2019
Environmental contours are widely used as a basis for e.g., ship design, especially in early design phases. The traditional approach to such contours is based on the well-known Rosenblatt transformation. In the present paper we present a numerical method making it possible to apply the inverse Rosenblatt transformation to mixtures of distributions. Due
Huseby, Arne, Vanem, Erik, Barbosa, Maria Hjelset   +2 more
openaire   +4 more sources

Bayesian multiple index models for environmental mixtures. [PDF]

Biometrics, 2023
AbstractAn important goal of environmental health research is to assess the risk posed by mixtures of environmental exposures. Two popular classes of models for mixtures analyses are response‐surface methods and exposure‐index methods. Response‐surface methods estimate high‐dimensional surfaces and are thus highly flexible but difficult to interpret ...
McGee G, Wilson A, Webster TF, Coull BA.
europepmc   +5 more sources

Comparison of environmental mixture methods for estimating the joint effects of environmental mixtures. [PDF]

Environ Res
Quantifying the health effects of environmental mixtures remains a methodological challenge, and while many mixture methods have emerged, few have been systematically compared. We evaluated five widely used approaches-weighted quantile sum regression (WQS), two-indices WQS (2iWQS), quantile g-computation (qgcomp), Bayesian kernel machine regression ...
Qian W, Eick SM, Zar HJ, Stein DJ, Chang HH, Hüls A.   +5 more
europepmc   +4 more sources

Workflow for Statistical Analysis of Environmental Mixtures. [PDF]

Environ Health Perspect
Human exposure to complex, changing, and variably correlated mixtures of environmental chemicals has presented analytical challenges to epidemiologists and human health researchers. There has been a wide variety of recent advances in statistical methods for analyzing mixtures data, with most methods having open-source software for implementation ...
Joubert BR, Palmer G, Dunson D, Kioumourtzoglou MA, Coull BA.   +4 more
europepmc   +4 more sources

Principal Component Pursuit for Pattern Identification in Environmental Mixtures. [PDF]

Environ Health Perspect, 2022
32 pages, 11 figures, 4 ...
Gibson EA, Zhang J, Yan J, Chillrud L, Benavides J, Nunez Y, Herbstman JB, Goldsmith J, Wright J, Kioumourtzoglou MA.   +9 more
europepmc   +4 more sources

Bridging environmental mixtures and toxic effects [PDF]

Environmental Toxicology and Chemistry, 2012
Abstract Biological Response Indicator Devices Gauging Environmental Stressors (BRIDGES) is a bioanalytical tool that combines passive sampling with the embryonic zebrafish developmental toxicity bioassay to provide a quantitative measure of the toxicity of bioavailable complex mixtures.
Sarah E, Allan, Brian W, Smith, Robert L, Tanguay, Kim A, Anderson   +3 more
openaire   +2 more sources

Computational characterisation of ecological hazard and risk of environmental mixtures. [PDF]

EFSA J
Abstract The project Computational characterisation of ecological hazard and risk of environmental mixtures focused on two key priorities in advancing a next‐generation risk assessment (NGRA) workflow: (i) transitioning to assessing mixtures and (ii) utilising mechanism‐based hazard assessment based on new approach methodology (NAM) data.
European Food Safety Authority (EFSA), Noventa S, Moe SJ, Tollefsen KE, Zobl W, Song Y, Manfra L, Lillicrap A.   +7 more
europepmc   +3 more sources

Ovarian Metabolism of an Environmentally Relevant Phthalate Mixture [PDF]

Toxicological Sciences, 2019
Phthalates are synthetic chemicals with widespread human exposure due to their use as additives in consumer products. Phthalate diesters are hydrolyzed in the environment and in the body to monoesters that may be more toxic than the parent compounds. This study tested the hypothesis that adult mouse antral follicles, but not neonatal ovaries, are able ...
Genoa R, Warner, Zhong, Li, Madeline L, Houde, Cassandra E, Atkinson, Daryl D, Meling, Catheryne, Chiang, Jodi A, Flaws   +6 more
openaire   +2 more sources

Estimation and false discovery control for the analysis of environmental mixtures [PDF]

Biostatistics, 2022
SummaryThe analysis of environmental mixtures is of growing importance in environmental epidemiology, and one of the key goals in such analyses is to identify exposures and their interactions that are associated with adverse health outcomes. Typical approaches utilize flexible regression models combined with variable selection to identify important ...
Samanta, Srijata, Antonelli, Joseph
openaire   +3 more sources

Effects and Interactions in an Environmentally Relevant Mixture of Pharmaceuticals [PDF]

Toxicological Sciences, 2007
With the goal of assessing the environmental risk of pharmaceuticals, we have previously observed that a mixture of 13 different drugs at environmentally relevant concentrations had adverse consequences on human and zebra fish cells in vitro. Here we aimed to identify both main and interaction effects within the same environmentally relevant mixture of
Francesco, Pomati, Chiara, Orlandi, Moira, Clerici, Fabio, Luciani, Ettore, Zuccato   +4 more
openaire   +2 more sources