Results 101 to 110 of about 3,084,334 (312)

Impact of Environmental Parameters on Marathon Running Performance

open access: yesPLoS ONE, 2012
The objectives of this study were to describe the distribution of all runners' performances in the largest marathons worldwide and to determine which environmental parameters have the maximal impact.We analysed the results of six European (Paris, London, Berlin) and American (Boston, Chicago, New York) marathon races from 2001 to 2010 through 1,791,972
El Helou, Nour   +7 more
openaire   +5 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Habitat use by Atherinella brasiliensis (Quoy & Gaimard, 1825) in intertidal zones of a subtropical estuary, Brazil

open access: yesActa Scientiarum: Biological Sciences, 2015
Habitat use is different along the ontogenetic development of some species and may be influenced by environmental parameters. This study described the interaction of Atherinella brasiliensis caught in intertidal areas of the Paranaguá Estuarine Complex ...
Barbara Maichak de Carvalho   +1 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Genetic parameters for birthweight environmental variability in mice

open access: yesJournal of Animal Breeding and Genetics, 2012
SummaryData from a divergent experiment for birthweight (BrW) environmental variability were used to estimate genetic parameters forBrWtrait and its environmental variability by fitting both homoscedastic (HO) and heteroscedastic (HE) models. A total of 5 475 records ofBrWfrom animals born from inbred dams, and 7 140 pedigree records were used.
Pun, A.   +6 more
openaire   +4 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Spatiotemporal Dynamics of Microcystin Variants and Relationships with Environmental Parameters in Lake Taihu, China

open access: yesToxins, 2015
Excessive anthropogenically-caused nutrient loading from both external and internal sources has promoted the growth of cyanobacteria in Lake Taihu from 2005 to 2014, suggesting increased production and release of cyanotoxins.
Xiaomei Su   +4 more
doaj   +1 more source

NKCC1: A key regulator of glioblastoma progression

open access: yesMolecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen   +5 more
wiley   +1 more source

Diversity and distribution of macrozoobenthos in Bojonegara coastal waters, Banten Bay, Indonesia [PDF]

open access: yesBIO Web of Conferences
Coastal ecosystems, essential for ecological stability, face escalating degradation from pollution and habitat loss. Bojonegara waters in Banten Bay experience anthropogenic pressure that may alter benthic communities. This study examined macrozoobenthos
Srimariana Endang Sunarwati   +5 more
doaj   +1 more source

Physiological spacecraft environment data documentation [PDF]

open access: yes
The physiological limits of exposure to environmental parameters encountered during space flight was documented. The environmental limits which have been previously established were described in terms of acceptable physiological changes.

core   +1 more source

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