Results 61 to 70 of about 13,194,862 (210)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Flywheel Resistance Training for Anterior Cruciate Ligament Rehabilitation

International Journal of Strength and Conditioning
The tearing or rupturing of the anterior cruciate ligament (ACL) has become an increasingly common injury in athletes, particularly in sports that require sharp, pivoting movements and sports that have high deceleration and landing demands.
Margaret Michalak, Chloe Ryan, Alex Ehlert, John Cronin   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Optimization of a Bamboo Continuous Flow Anaerobic Bio-Degumming System Through Pretreatment Screening

Journal of Natural Fibers
This research used a spiral symmetry stream anaerobic bioreactor (SSSAB) to establish and optimize a continuous flow anaerobic bio-degumming system (CFAB) for bamboo fibers.
Muqadas Mustafa, Liu Xiaoyue, Li Mingxi, Xie Xuehui, Ren Luotong, Li Yuling, Edouard Bugingo, Chen Xiaoguang   +7 more
doaj   +1 more source

Corporate Environmental Performance: Consistency of Metrics and Identification of Drivers [PDF]

This study is among the first to provide insight into the assessment of the convergent validity of widely used environmental performance ratings. Using a set of environmental dimensions in KLD, GES, and ASSET4 ratings, this study demonstrates that the ...
Semenova, Natalia
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The Effect of Lightweight Wearable Resistance on the Squat and Countermovement Jumps: Does Load Dampen the Performance-Enhancing Effect of the Stretch-Shortening Cycle?

Applied Sciences
This study investigated the effects of lightweight wearable resistance on the kinetics and kinematics of squat jumps (SJ) and countermovement jumps (CMJ) with 2%, 4%, and 6% body mass (BM). Twenty male athletes (age: 18.05 ± 0.6 years; weight: 76.4 ± 7.6
Hamish Kyne, John B. Cronin
doaj   +1 more source

IT Innovativeness and Environmental Consciousness on Organizational Performance [PDF]

The purpose of our study is to investigate the impacts of Information Technology (IT) innovation and environmental consciousness on firm performance. We tested the robustness of innovation theory using the most recent Information Week (IW) 500 annual ...
Myung Ko
core  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source