Results 101 to 110 of about 3,729,294 (289)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Improved Diet Quality in Elite and Entry-Level Military Women Compared With Civilian-Matched Counterparts

Current Developments in Nutrition
Background: Dietary intake is a modifiable factor linked to short-term and long-term health. The Healthy Eating Index (HEI) is an objective measure to assess diet quality and population-level comparisons, like military to civilian. Objectives: This study
Tyler E Oliver, Soothesuk Kusumpa, Laura J Lutz, James P McClung, Holly L McClung   +4 more
doaj   +1 more source

A Concept for Multi-Criteria Environmental Assessment of Aircraft Trajectories

Aerospace, 2017
Comprehensive assessment of the environmental aspects of flight movements is of increasing interest to the aviation sector as a potential input for developing sustainable aviation strategies that consider climate impact, air quality and noise issues ...
Sigrun Matthes, Volker Grewe, Katrin Dahlmann, Christine Frömming, Emma Irvine, Ling Lim, Florian Linke, Benjamin Lührs, Bethan Owen, Keith Shine, Stavros Stromatas, Hiroshi Yamashita, Feijia Yin   +12 more
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Menstrual Health in Servicewomen: The Menstrual Cycle, Menstrual Disturbances, and Occupational Consequences

Sports Medicine - Open
Background Most women serving in the military do so during their reproductive life and enter service at a young gynecological age. This review provides an overview of the menstrual cycle and summarizes the evidence for menstrual cycle disturbances in the
Ritva S. Mikkonen, Holly McClung, Gabrielle Giersch, Jeroen Van Cutsem, Helen Wright, Thomas J. O’Leary, Julie P. Greeves   +6 more
doaj   +1 more source

Determinants of Environmental and Economic Performance of Firms: An Empirical Analysis of the European Paper Industry [PDF]

This paper examines the relationship between the environmental and economic performance of firms in the European paper manufacturing industry. Based on panel data, it first investigates the relationship separately, with the analysis based on four ...
Marcus WAGNER, Phu NGUYEN VAN, Théophile AZOMAHOU   +2 more
core  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Bayesian analysis of the linear reaction norm model with unknown covariate [PDF]

, 2006
The reaction norm model is becoming a popular approach for the analysis of G x E interactions. In a classical reaction norm model, the expression of a genotype in different environments is described as a linear function (a reaction norm) of an ...
Jensen, J., Korsgaard, I.R., Lund, M.S., Madsen, P., Su, G., Sørensen, D.   +5 more
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source