Results 61 to 70 of about 896,772 (267)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Association between salivary and blood hormone concentrations using an automated electrochemiluminescence immunoassay technique: Challenges and pitfalls

Experimental Physiology
Blood‐based measures are considered the gold standard for evaluating steroid hormone concentrations, particularly for confirmation of hormone profiles in female‐specific research.
Natalie J. Hardaker, Patria A. Hume, Stacy T. Sims, Tom Stewart, Doug A. King   +4 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Reliability of a Portable Fixed Dynamometer During Different Isometric Hamstring Assessments

Applied Sciences
Hamstring strain injuries are one of the most common non-contact injuries in sport. Hamstring strength and asymmetry are two key modifiable risk factors for hamstring strain injuries; therefore, it seems important to find reliable tests for assessing ...
Ryan Woodbridge, Chloe Ryan, Josh Burkitt, Dana Ye-Lee, John Cronin   +4 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Financial Performance To Environmental Disclosure With Environmental Performance As Moderation

, 2018
The purpose of this study was determined the effect of profitability and growth rates of the company's assets on environmental disclosure with environmental performance as a moderating variable. Environmental disclosure is a dependent variable, while profitability and growth rates of the company's assets an independent variable.
openaire   +2 more sources

Characterising performance of environmental models

Environmental Modelling & Software, 2013
In order to use environmental models effectively for management and decision-making, it is vital to establish an appropriate level of confidence in their performance. This paper reviews techniques available across various fields for characterising the performance of environmental models with focus on numerical, graphical and qualitative methods ...
Neil D. Bennett, Barry F. W. Croke, Giorgio Guariso, Joseph H. A. Guillaume, Serena H. Hamilton, Anthony J. Jakeman, Stefano Marsili-Libelli, Lachlan T. H. Newham, John P. Norton, Charles Perrin, Suzanne A. Pierce, Barbara J. Robson, Ralf Seppelt, Alexey A. Voinov, Brian D. Fath, Vazken Andréassian   +15 more
openaire   +7 more sources

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Female RNA concussion (FeRNAC) study: assessing hormone profiles and salivary RNA in females with concussion by emergency departments in New Zealand: a study protocol

BMC Neurology
Background Females of reproductive age with concussion report a greater number of symptoms that can be more severe and continue for longer than age matched males. Underlying mechanisms for sex differences are not well understood.
Natalie Hardaker, Doug King, Patria A. Hume, Tom Stewart, Stacy Sims, Indira Basu, Blair Shilton, James Selfe   +7 more
doaj   +1 more source